Paget's disease

Paget's disease
Pag·et's disease .paj-əts- n
1) a rare form of breast cancer initially manifested as a scaly red rash on the nipple and areola
2) a chronic disease of bones characterized by their great enlargement and rarefaction with bowing of the long bones and deformation of the flat bones called also osteitis deformans, osteodystrophia deformans

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1. a chronic disease of bones, occurring in the elderly and most frequently affecting the skull, backbone, pelvis, and long bones. Affected bones become thickened and their structure disorganized: X-rays reveal patchy sclerosis. There are often no symptoms, but pain, deformity, and fracture can occur; when the skull is affected, blindness and deafness can occur due to nerve compression. There is a very small (1%) risk of malignant change (osteosarcoma). Treatment is with bisphosphonates or calcitonin. Medical name: osteitis deformans.
2. a malignant condition of the nipple, resembling eczema in appearance, associated with underlying infiltrating cancer of the breast. See also breast cancer.
3. an uncommon condition of the vulva characterized by an epithelial lesion that histologically resembles the lesion of Paget's disease of the nipple. It may be associated with locally invasive adenocarcinoma of the surrounding skin, as well as tumours at other sites.
Sir J. Paget (1814-99), British surgeon

Medical dictionary. 2011.

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Look at other dictionaries:

  • Paget's disease — n. 1. a disease that deforms and weakens bones, in which rapid decalcification is followed by excessive calcification 2. a type of cancer usually involving the breast s larger ducts, areola, and nipple …   English World dictionary

  • Paget's disease — Sir James Paget, a surgeon and pathologist, described several diseases, including: Paget s disease of bone (most common use of Paget s disease) Paget s disease of the breast Paget Schroetter disease Extramammary Paget s disease (EMPD) This… …   Wikipedia

  • Paget-Schroetter disease — Infobox Disease Name = Paget Schroetter disease Caption = Anterior view of right upper limb and thorax DiseasesDB = 34349 ICD10 = ICD10|I|82|8|i|80 ICD9 = ICD9|453.8 ICDO = OMIM = MedlinePlus = eMedicineSubj = med eMedicineTopic = 2772 MeshID =… …   Wikipedia

  • Paget's disease — 1) a chronic disease of bones, occurring in the elderly and most frequently affecting the skull, backbone, pelvis, and long bones. Affected bones become thickened and their structure disorganized: X rays reveal patchy sclerosis. There are often… …   The new mediacal dictionary

  • Paget's disease of the breast — Paget s disease of the breast, also known as Paget s disease of the nipple, is a condition that outwardly may have the appearance of eczema with skin changes involving the nipple of the breast. Because of its seemingly innocuous and surface… …   Wikipedia

  • Paget's disease of bone — For other diseases named after Paget, see Paget s disease (disambiguation). Paget s disease of bone Classification and external resources This 92 year old male patient presented for assessment of acute hemiparesis. An incidental finding was… …   Wikipedia

  • Paget's disease of bone — A chronic bone disorder that typically results in enlarged, deformed bones due to excessive breakdown and formation of bone tissue that can cause bones to weaken and may result in bone pain, arthritis, deformities or fractures. The disease is… …   Medical dictionary

  • Paget's disease of the breast — The combination of scaly skin changes of the nipple resembling eczema and an underlying cancer of the breast. The nipple is inflamed because of the presence of Paget s cells. These large irregular cells are themselves not cancerous, but they are… …   Medical dictionary

  • Paget's disease — Pag′et s disease [[t]ˈpædʒ ɪts[/t]] n. 1) pat a disease characterized by episodic accelerated bone resorption and growth of abnormal replacement bone 2) pat an inflammatory condition of the nipple associated with breast cancer Etymology: 1875–80; …   From formal English to slang

  • Paget's disease — noun Etymology: Sir James Paget died 1899 English surgeon Date: 1880 1. a rare form of breast cancer initially manifested as a scaly red rash on the nipple and areola 2. a chronic disease in which the bones become enlarged, weak, and deformed …   New Collegiate Dictionary

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