McArdle's disease

McArdle's disease
McArdle's disease, McBurney's point see entries alphabetized as MC-
Mc·Ar·dle's disease mək-'ärd-əlz- n glycogen storage disease that is inherited as an autosomal recessive trait, is marked esp. by muscle weakness and myoglobinuria, and is caused by deficiency of a phosphorylase normally present in skeletal muscle called also McArdle's syndrome
McArdle Brian (1911-2002)
British physician. McArdle served on the staff of the department of chemical pathology at a London hospital. He was the author of articles on diseases of the muscle. In 1951 he published a paper on myopathy due to a defect in muscle glycogen breakdown. His report was based on the study of a 30-year-old male who had had the disease since childhood.

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an inborn error of metabolism in which a deficiency of the enzyme myophosphorylase prevents the breakdown of glycogen to lactate in exercising muscle. This results in fatigue, pain, and cramps in exercising muscles. The only treatment is avoidance of sustained or excessive exercise.
B. McArdle (20th century), British biochemist

Medical dictionary. 2011.

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Look at other dictionaries:

  • McArdle's disease — ▪ pathology also called  Glycogenosis Type V,         rare hereditary deficiency of the enzyme glycogen phosphorylase in muscle cells. In the absence of this enzyme, muscles cannot break down animal starch (glycogen) to meet the energy… …   Universalium

  • McArdle's disease — noun an inherited disease in which abnormal amounts of glycogen accumulate in skeletal muscle; results in weakness and cramping • Hypernyms: ↑genetic disease, ↑genetic disorder, ↑genetic abnormality, ↑genetic defect, ↑congenital disease,… …   Useful english dictionary

  • McArdle's disease — an inborn error of metabolism in which a deficiency of the enzyme myophosphorylase prevents the breakdown of glycogen to lactate in exercising muscle. This results in fatigue, pain, and cramps in exercising muscles. The only treatment is… …   The new mediacal dictionary

  • McArdle's disease — Glycogen storage disease in which the defective enzyme is muscle phosphorylase …   Dictionary of molecular biology

  • McArdle's disease — noun Glycogen storage disease type V, a metabolic disorder caused by a deficiency of myophosphorylase …   Wiktionary

  • McArdle — Irish name:MacArdghail Ethnicity Irish/Celtic Information Place of origin County Monaghan, Ireland[1] Notable members …   Wikipedia

  • McArdle-Krankheit — Klassifikation nach ICD 10 E74.0 Glykogenspeicherkrankheit (Glykogenose) McArdle Krankheit …   Deutsch Wikipedia

  • McArdle-Syndrom — Klassifikation nach ICD 10 E74.0 Glykogenspeicherkrankheit (Glykogenose) McArdle Krankheit …   Deutsch Wikipedia

  • McArdle disease — McArdle disease. См. гликогеноз V типа. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • McArdle disease (syndrome) — Mc·Ar·dle disease (syndrome) (mək ahrґdəl) [Brian McArdle, English neurologist, 1911–2002] see glycogen storage disease, type V, under disease …   Medical dictionary

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