malate dehydrogenase

malate dehydrogenase n an enzyme that catalyzes reversibly the oxidation of malate in the presence of NAD called also malic enzyme

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ma·late de·hy·dro·gen·ase (maґlāt de-hiґdro-jən-ās) [EC 1.1.1.37] an enzyme of the oxidoreductase class that catalyzes the oxidation of L-malate to oxaloacetate, reducing NAD^{+>. The enzyme occurs both in the mitochondria and in the cytosol. The reaction is important in the tricarboxylic acid cycle and in the malate-aspartate electron shuttle. See illustration at} tricarboxylic acid cycle, under cycle.