leukotriene

leukotriene
leu·ko·tri·ene .lü-kə-'trī-.ēn n any of a group of eicosanoids that are generated in basophils, mast cells, macrophages, and human lung tissue by lipoxygenase-catalyzed oxygenation esp. of arachidonic acid and that participate in allergic responses (as bronchoconstriction in asthma) see SLOW-REACTING SUBSTANCE OF ANAPHYLAXIS

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n.
one of a class of powerful chemical agents synthesized from arachidonic acid by mast cells, basophils, macrophages, and various other tissues. Leukotrienes are involved in inflammatory reactions and the immune response: they increase the permeability of small blood vessels, cause contraction of smooth muscle, and attract neutrophils to the site of an infection.

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leu·ko·tri·ene (loo″ko-triґēn) [from leukocytes + triene indicating three double bonds] any of a group of biologically active compounds consisting of straight chain, 20-carbon carboxylic acids with one or two oxygen substituents and three or more conjugated double bonds. They are formed from arachidonic acid by the lipoxygenase pathway and function as regulators of allergic and inflammatory reactions. Leukotrienes are identified by letters A, B, C, D, and E, with subscripts indicating the number of double bonds in the molecule. Some (e.g., LTB4) stimulate the movement of leukocytes; three others (LTC4, LTD4, and LTE4) together constitute slow-reacting substance of anaphylaxis, which causes bronchial constriction and other allergic reactions.

Medical dictionary. 2011.

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  • leukotriene — [lo͞o΄kō trī′ēn΄, lo͞o΄kətrī′ēn΄] n. [ LEUKO (var. of LEUCO ) + TRI + ENE: it contains three double bonds] any of a group of compounds similar to the prostaglandins, which are released in the body when various cells are stimulated as by pollen,… …   English World dictionary

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  • Leukotriene C4 synthase — Leukotriene C4 synthase, also known as LTC4S, is a human gene.cite web | title = Entrez Gene: LTC4S leukotriene C4 synthase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=4056| accessdate = ] The protein… …   Wikipedia

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