Lambert-Eaton syndrome

Lambert-Eaton syndrome
Lam·bert-Ea·ton syndrome 'lam-bərt-'ēt-ən- n an autoimmune disorder that is caused by impaired presynaptic release of acetylcholine at nerve synapses, that resembles myasthenia, that is characterized by weakness usu. affecting the limbs but not the ocular and bulbar muscles, and that is often associated with carcinoma of the lung called also Eaton-Lambert syndrome, Lambert-Eaton myasthenic syndrome
Lambert Edward Howard (b 1915), and
Eaton Lealdes McKendree (1905-1958)
American physicians. Lambert and Eaton spent the bulk of their careers at the Mayo Clinic in Rochester, Minnesota. At the Mayo Medical School Lambert served for many years as professor of physiology and in later years also as professor of neurology. Eaton rose to the position of professor of neurology and head of the Clinic's neurologic section. Lambert's areas of research included neurophysiology, electromyography, and various human neuromuscular disorders. Eaton's own research topics included myasthenia gravis and polymyositis. Lambert and Eaton were the principal authors of a 1956 article describing the syndrome which now bears their names.

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Lambert-Eaton myasthenic syndrome (LEMS) an autoimmune, myasthenialike syndrome caused by autoantibodies to the voltage-gated calcium channel (anna 1 antibodies) that interfere with the release of acetylcholine at the motor nerve terminal. Weakness usually affects the limbs, but ocular and bulbar muscles are spared; there is reduced muscle action potential on stimulation of its nerve but with repetitive stimulation it becomes augmented. It is often associated with oat-cell carcinoma of the lung. Called also Eaton-Lambert s. and myasthenic s.

Medical dictionary. 2011.

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  • Lambert-Eaton syndrome — noun a disease seen in patients with lung cancer and characterized by weakness and fatigue of hip and thigh muscles and an aching back; caused by antibodies directed against the neuromuscular junctions • Syn: ↑Eaton Lambert syndrome, ↑myasthenic… …   Useful english dictionary

  • Lambert-Eaton syndrome (myasthenic syndrome) — Lam·bert Ea·ton syndrome (myasthenic syndrome) (lamґbərt eґton) [Edward Howard Lambert, American physiologist, 1915–2003; Lealdes McKendree Eaton, American neurologist, 1905–1958] see under syndrome …   Medical dictionary

  • Syndrome myasthenique de Lambert-Eaton — Syndrome myasthénique de Lambert Eaton Décrit en 1956[1], le syndrome de Lambert Eaton représente avec le botulisme, le modèle des dysfonctionnements de la jonction neuro musculaire de type présynaptique, par opposition aux désordres de type… …   Wikipédia en Français

  • Syndrome myasthénique de lambert-eaton — Décrit en 1956[1], le syndrome de Lambert Eaton représente avec le botulisme, le modèle des dysfonctionnements de la jonction neuro musculaire de type présynaptique, par opposition aux désordres de type postsynaptiques dont le type le plus… …   Wikipédia en Français

  • Syndrome myasthénique de Lambert-Eaton — Décrit en 1956[1], le syndrome de Lambert Eaton représente avec le botulisme, le modèle des dysfonctionnements de la jonction neuro musculaire de type présynaptique, par opposition aux désordres de type postsynaptiques dont le type le plus… …   Wikipédia en Français

  • Lambert-Eaton myasthenic syndrome — Infobox Disease Name = PAGENAME Caption = Detailed view of a neuromuscular junction: 1. Presynaptic terminal 2. Sarcolemma 3. Synaptic vesicle 4. Nicotinic acetylcholine receptor 5. Mitochondrion DiseasesDB = 4030 ICD10 = ICD10|G|73|1|g|70 ICD9 …   Wikipedia

  • Lambert-Eaton-Rooke-Syndrom — Klassifikation nach ICD 10 G73* Krankheiten im Bereich der neuromuskulären Synapse und des Muskels bei anderenorts klassifizierten Krankheiten G73.1* Eaton Lambert Syndrom …   Deutsch Wikipedia

  • Lambert-Eaton-Syndrom — Klassifikation nach ICD 10 G73* Krankheiten im Bereich der neuromuskulären Synapse und des Muskels bei anderenorts klassifizierten Krankheiten G73.1* Eaton Lambert Syndrom …   Deutsch Wikipedia

  • Eaton-Lambert syndrome — n LAMBERT EATON SYNDROME * * * Ea·ton Lam·bert syndrome (eґton lamґbərt) [Lealdes McKendree Eaton, American neurologist, 1905–1958; Edward H. Lambert, American physiologist, 1915–2003] Lambert Eaton myasthenic syndrome; see under… …   Medical dictionary

  • Eaton-Lambert syndrome — noun a disease seen in patients with lung cancer and characterized by weakness and fatigue of hip and thigh muscles and an aching back; caused by antibodies directed against the neuromuscular junctions • Syn: ↑Lambert Eaton syndrome, ↑myasthenic… …   Useful english dictionary

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