lactic acidosis

lactic acidosis
lactic acidosis n a condition characterized by the accumulation of lactic acid in bodily tissues

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excessive plasma acidity due to an accumulation of lactic acid. This may be caused by a variety of illnesses, including heart failure or severe dehydration. It can also be caused by the accumulation of biguanide drugs used for treating type 2 diabetes mellitus, particularly when kidney failure is present. Biguanides (see metformin) should therefore not be used to treat patients who also have kidney disease or heart failure or who are dehydrated.

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a metabolic acidosis occurring as a result of excess lactic acid in the blood, due to conditions causing impaired cellular respiration. It occurs most commonly in disorders in which O2 is inadequately delivered to tissues, e.g., shock, septicemia, or extreme hypoxemia, but it can also result from exogenous or endogenous metabolic defects. Initially manifesting as hyperventilation, it progresses to mental confusion and coma.

Medical dictionary. 2011.

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