intrinsic factor

intrinsic factor
intrinsic factor n a substance produced by the normal gastrointestinal mucosa that facilitates absorption of vitamin B12

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a glycoprotein secreted in the stomach. The secretion of intrinsic factor is necessary for the absorption of vitamin B12; a failure of secretion of intrinsic factor leads to a deficiency of the vitamin and the condition of pernicious anaemia.

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a glycoprotein secreted by the parietal cells of the gastric glands, necessary for the absorption of vitamin B12> (cyanocobalamin). Lack of intrinsic factor, with consequent deficiency of vitamin B12>, results in pernicious anemia.

Medical dictionary. 2011.

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  • intrinsic factor — intrinsic factor, in den Belegzellen der Magenschleimhaut gebildetes Glykoprotein, das mit ⇒ Cobalamin zu einem Komplex zusammentritt und so die Resorption dieses Vitamins im Dünndarm ermöglicht. Wird i. f. in unzureichendem Maß gebildet, kommt… …   Deutsch wörterbuch der biologie

  • intrinsic factor — n. a substance secreted by the stomach which permits the absorption of vitamin B12 in the intestines, thus preventing pernicious anemia …   English World dictionary

  • Intrinsic factor — protein Name = Gastric intrinsic factor caption = width = HGNCid = 4268 Symbol = GIF AltSymbols = EntrezGene = 2694 OMIM = 609342 RefSeq = NM 005142 UniProt = P27352 PDB = ECnumber = Chromosome = 11 Arm = q Band = 13 LocusSupplementaryData =… …   Wikipedia

  • intrinsic factor — Biochem. a glycoprotein, secreted by the gastric mucosa, that is involved in the intestinal absorption of vitamin B12. [1925 30] * * * ▪ protein       a glycoprotein (i.e., a complex compound containing both polysaccharide and protein components) …   Universalium

  • Intrinsic Factor — Der Intrinsic Faktor ist ein Glykoprotein und dient der Aufnahme von Cobalamin (Vitamin B12, Extrinsic Factor) im terminalen Ileum (Hüftdarm). Inhaltsverzeichnis 1 Physiologische Bedeutung 2 Wirkungsweise 3 Krankheiten 4 Literatur …   Deutsch Wikipedia

  • intrinsic factor — a glycoprotein secreted in the stomach. The secretion of intrinsic factor is necessary for the absorption of vitamin B 12; a failure of secretion of intrinsic factor leads to a deficiency of the vitamin and the condition of pernicious anaemia …   The new mediacal dictionary

  • Intrinsic factor — In|trinsic factor [intrịnßik fạ̈kter; aus gleichbed. engl. intrinsic factor (eigtl. = von innen wirkender Faktor)] m; [s], s: Bezeichnung für ein normalerweise in den Fundusdrüsen des Magens u. im oberen Abschnitt des Zwölffingerdarms… …   Das Wörterbuch medizinischer Fachausdrücke

  • Intrinsic Factor — In|trin|sic Fac|tor [ fæktə] der; [s], s <aus gleichbed. engl. intrinsic factor, eigtl. »von innen wirkender Faktor«> Bez. für ein in den ↑Fundusdrüsen des Magens u. im oberen Abschnitt des Zwölffingerdarms produziertes Enzym, das zusammen… …   Das große Fremdwörterbuch

  • intrinsic factor — noun a substance produced by the mucosa of the stomach and intestines that is essential for the absorption of vitamin B12 lack of intrinsic factor can result in pernicious anemia • Hypernyms: ↑factor …   Useful english dictionary

  • intrinsic factor — A mucoprotein normally secreted by the epithelium of the stomach and that binds vitamin B12; the intrinsic factor/B12 complex is selectively absorbed by the distal ileum, though only the vitamin is taken into the cell …   Dictionary of molecular biology

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