- ifos·fa·mide .ī-'fäs-fə-.mīd n a synthetic cyclophosphamide analog C7H15Cl2H7O2P that is pharmacologically inert until activated by liver enzymes after being administered by injection for the treatment esp. of testicular cancer
* * *n.a cytotoxic drug (an alkylating agents) used in the treatment of malignant disease, particularly sarcomas, testicular tumours, and lymphomas. It is administered intravenously by injection or infusion. Side-effects include nausea, vomiting, alopecia, and haemorrhagic cystitis; concomitant administration of mesna is recommended to prevent cystitis. Trade name: Mitoxana.
* * *ifos·fa·mide (i-fosґfə-mīd) [USP] a cytotoxic alkylating agent of the nitrogen mustard group, a structural analogue of and similar in action to cyclophosphamide; it is itself pharmacologically inert and must be activated by the microsomal enzyme system of the liver. Used in the treatment of solid tumors of the testis, ovary, and lung as well as sarcomas; administered intravenously.
Medical dictionary. 2011.