high-density lipoprotein

high-density lipoprotein
high-density lipoprotein n HDL

* * *

(HDL) any of a class of lipoproteins frequently divided into HDL2 and HDL3 (see table) and the minor variant HDL1 (see Lp(a) l.). HDL promotes transport of cholesterol from extrahepatic tissue to the liver for excretion in the bile; synthesized by the liver as discoid “nascent HDL” particles lacking a lipid core, it accumulates a core of cholesteryl esters during reverse cholesterol transport (q.v.) and transfers them to the liver directly or indirectly via other lipoproteins. HDL also shuttles apolipoproteins C-II and E to and from triglyceride-rich lipoproteins during catabolism of the lipoproteins. Serum HDL cholesterol has been negatively correlated with coronary heart disease. Called also (referring to its electrophoretic mobility) α-l.

Medical dictionary. 2011.

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