creatine kinase

creatine kinase
creatine kinase n any of three isoenzymes found esp. in vertebrate skeletal and myocardial muscle and the brain that catalyze the transfer of a high-energy phosphate group from phosphocreatine to ADP with the formation of ATP and creatine and typically occur in elevated levels in the blood following injury to brain or muscle tissue

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an enzyme involved in the metabolic breakdown of creatine to creatinine. Isomers of creatine kinase originate from brain and thyroid (BB), skeletal muscle (MM), and cardiac muscle (MB). Any damage to these tissues causes an increase of the isomer in the serum, which can be used in diagnosis, particularly of myocardial infarction.

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cre·a·tine ki·nase (CK) (kreґə-tin kiґnās) [EC 2.7.3.2] an Mg2+-activated enzyme of the transferase class that catalyzes the phosphorylation of creatine by ATP to form phosphocreatine. The reaction effectively stores the energy of ATP as phosphocreatine in muscle and brain tissue and holds the muscle concentration of ATP nearly constant during the initiation of exercise. It occurs as three isoenzymes, each having two components composed of M (muscle) and of B (brain) subunits. CK1 (BB) is found primarily in brain, CK2 (MB) primarily in cardiac muscle, and CK3 (MM) primarily in skeletal muscle. Differential determination of isoenzymes is useful for clinical diagnoses.

Medical dictionary. 2011.

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  • créatine phosphokinase, créatines phosphokinases ou créatine kinase, créatines kinases — ● créatine phosphokinase, créatines phosphokinases ou créatine kinase, créatines kinases nom féminin Enzyme musculaire dont le taux sérique s élève en cas d infarctus du myocarde …   Encyclopédie Universelle

  • creatine kinase — (= creatine phosphokinase) (EC 2.7.3.2.) Dimeric enzyme (82 kD) that catalyses the formation of ATP from ADP and creatine phosphate in muscle …   Dictionary of molecular biology

  • creatine kinase — noun Date: 1964 any of three isoenzymes found especially in vertebrate skeletal and myocardial muscle that catalyze the transfer of a high energy phosphate group from phosphocreatine to ADP with the formation of ATP and creatine …   New Collegiate Dictionary

  • creatine kinase — noun An enzyme that catalyzes the phosphorylation of creatine …   Wiktionary

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