Radioimmunoassay

Radioimmunoassay
A very sensitive, specific laboratory test (assay) using radiolabeled (and unlabeled) substances in an immunological (antibody-antigen) reaction.
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An immunologic (immunochemical) procedure that uses the competition between radioisotope-labeled antigen or other substance and unlabeled antigen for antiserums, resulting in quantitation of the unlabeled antigen; any method for detecting or quantitating antigens or antibodies using radiolabeled reactants. Minute quantities of enzymes, hormones, or other substances can be assayed.

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ra·dio·im·mu·no·as·say .rād-ē-ō-.im-yə-nō-'as-.ā, -im-.yü-, -a-'sā n immunoassay of a substance (as insulin) that has been radiolabeled abbr. RIA
ra·dio·im·mu·no·as·say·able -ə-bəl adj

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n.
a technique using radioactive antibodies as tracer to estimate the levels of natural substances in a blood sample. The antibodies bind to antigens, and the amount of radioactivity trapped is a measure of the amount of the target antigen present. The technique is widely used in the estimation of hormone levels.

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ra·dio·im·mu·no·as·say (ra″de-o-im″u-no-asґa) a highly sensitive and specific assay method that uses the competition between radiolabeled and unlabeled substances in an antigen-antibody reaction to determine the concentration of the unlabeled substance; it can be used to determine antibody concentrations or to determine the concentration of any substance against which specific antibody can be produced. Abbreviated RIA.

Medical dictionary. 2011.

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  • Radioimmunoassay — (RIA) is a scientific method used to test antigens (for example, hormone levels in the blood) without the need to use a bioassay. It was developed by Rosalyn Yalow and Solomon Aaron Berson in the 1950s. [Yalow RS, Berson SA. Immunoassay of… …   Wikipedia

  • radioimmunoassay — ☆ radioimmunoassay [rā′dē ōim΄yoo nō as′ā, rā′dē ō im΄yoo nōa sā′ ] n. the technique of immunoassay in which radioactive tracers are introduced into the substance to be analyzed …   English World dictionary

  • Radioimmunoassay — Ein Radioimmunoassay (RIA) ist eine Labormethode zur quantitativen Bestimmung kleinster Substanzmengen. Kleine Konzentrationen von Hormonen, Enzymen, Tumorantigenen, Infektionsantigenen, Arzneimitteln und DNA können mit dieser… …   Deutsch Wikipedia

  • radioimmunoassay — noun Date: 1961 immunoassay of a substance that has been radioactively labeled • radioimmunoassayable adjective …   New Collegiate Dictionary

  • radioimmunoassay — (RIA; ra de o im u no as a) A very sensitive assay technique that uses a purified radioisotope labeled antigen or antibody to compete for antibody or antigen with unlabeled standard and samples to determine the concentration of a substance in the …   Dictionary of microbiology

  • radioimmunoassay — Any system for testing antigen antibody reactions in which use is made of radioactive labelling of antigen or antibody to detect the extent of the reaction …   Dictionary of molecular biology

  • radioimmunoassay — /ray dee oh im yeuh noh as ay, a say , i myooh /, n. a test procedure that integrates immunologic and radiolabeling techniques to measure minute quantities of a substance, as a protein, hormone, or drug, in a given sample of body fluid or tissue …   Universalium

  • radioimmunoassay — noun A procedure that uses the binding of a radioactively labeled substance to an antibody in order to analyze minute amounts of biological compounds …   Wiktionary

  • Radioimmunoassay — Ra|di|o|im|mu|no|as|say 〈[ əsɛı] n.; Gen.: s, Pl.: s; Chemie〉 Verfahren der analyt. Immunchemie, bei dem mithilfe eines radioaktiv markierten Antigens od. Antikörpers eine Immunreaktion erzeugt wird, die Schlüsse auf die Qualität u. Quantität der …   Lexikalische Deutsches Wörterbuch

  • radioimmunoassay — noun Medicine a technique for measuring antibody levels using radioactively labelled antigens …   English new terms dictionary

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