Pernicious anemia

Pernicious anemia
A blood disorder caused by inadequate vitamin B12 in the blood. Patients who have this disorder do not produce the substance in the stomach that allows the body to absorb vitamin B12. This substance is called intrinsic factor (IF). Pernicious anemia is characterized by the presence in the blood of large, immature, nucleated cells (megaloblasts) that are forerunners of red blood cells. (Red blood cells, when mature, have no nucleus). It is thus a type of megaloblastic anemia. Pernicious anemia (PA) was first described (although not by that name) in 1855 by the English physician Thomas Addison. He called it an invariably fatal “idiopathic anemia.” The “idiopathic” was a frank admission that the cause of this illness was wholly unknown. The name “pernicious anemia” was coined in 1872 by the German physician Anton Biermer whose description of the disease was superior to that of Addison. The studies of George H. Whipple on the effects of feeding liver in anemia followed by those of George R. Minot and Wm. P. Murphy on the effects of feeding liver specifically in pernicious anemia (PA) led to the cure of PA and to their receiving the Nobel Prize in 1934. Nowadays PA is an unpernicious anemia. It is simply treated with vitamin B12. The vitamin B12 has to be administered by injection because people with PA do not have IF (or an effective form of IF) and so cannot absorb vitamin B12 taken by mouth. There is some evidence that PA may be genetic although its mode of inheritance is poorly documented. There is a congenital form of PA due to defect of IF that is clearly inherited as an autosomal recessive trait with the affected child having received two copies of the gene, one from each parent. The IF gene itself has been localized to human chromosome 11. The word "pernicious" means highly injurious, destructive, or deadly. "Pernicious" comes from the Latin root "nex" meaning "violent death." Pernicious anemia was once quite deadly. Today it fortunately is not. PA has also been called Addison’s anemia, addisonian anemia,

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pernicious anemia n a severe hyperchromic anemia marked by a progressive decrease in number and increase in size and hemoglobin content of the red blood cells and by pallor, weakness, and gastrointestinal and nervous disturbances and associated with reduced ability to absorb vitamin B12 due to the absence of intrinsic factor called also addisonian anemia

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a type of megaloblastic anemia usually seen in older adults, caused by impaired intestinal absorption of vitamin B12> due to lack of availability of intrinsic factor; it is often characterized by pallor, achlorhydria, glossitis, gastric mucosal atrophy, weakness, antibodies against gastric parietal cells or intrinsic factor, and neurologic manifestations.

Medical dictionary. 2011.

Look at other dictionaries:

  • Pernicious anemia — Classification and external resources ICD 10 D51.0 ICD 9 281.0 …   Wikipedia

  • pernicious anemia — n. a form of anemia characterized by a gradual reduction in the number of the red blood cells, gastrointestinal and nervous disturbances, etc., due to a deficiency of vitamin B12 …   English World dictionary

  • pernicious anemia — Pathol. a severe anemia caused by the diminution or absence of stomach acid secretion, with consequent failure of the gastric mucosa to secrete the intrinsic factor necessary for the absorption of vitamin B12, characterized by a great reduction… …   Universalium

  • pernicious anemia — malignant anemia malignant anemia n. (Med.) A chronic progressive anemia of older adults, thought to result from a lack of intrinsic factor (a substance secreted by the stomach that is responsible for the absorption of vitamin B 12); also called… …   The Collaborative International Dictionary of English

  • pernicious anemia — noun a chronic progressive anemia of older adults; thought to result from a lack of intrinsic factor (a substance secreted by the stomach that is responsible for the absorption of vitamin B12) • Syn: ↑pernicious anaemia, ↑malignant anemia,… …   Useful english dictionary

  • pernicious anemia — see pernicious anaemia …   English dictionary

  • pernicious anemia — noun Date: 1874 a severe megaloblastic anemia that is marked by a progressive decrease in the number of red blood cells and by pallor, weakness, and gastrointestinal and nervous disturbances and is caused by malabsorption of vitamin B12 due to… …   New Collegiate Dictionary

  • pernicious anemia — noun A severe form of anemia caused by vitamin B insufficiency …   Wiktionary

  • pernicious anemia — per,nicious a nemia noun uncount MEDICAL a type of ANEMIA that can cause death if it is not treated …   Usage of the words and phrases in modern English

  • pernicious anemia — n. severe form of anemia affecting mostly older people …   English contemporary dictionary

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