Methemoglobin

A particular type of hemoglobin that is altered so that it is useless for carrying oxygen and delivering it to tissues throughout the human body. Since hemoglobin is the key carrier of oxygen in the blood, its wholesale replacement by methemoglobin can cause cyanosis (a slate gray-blueness) due to lack of oxygen. A small amount of methemoglobin is normally present in blood but the conversion of a larger fraction of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier, results in perceptible cyanosis. In technical terms, methemoglobin is a transformation product of normal hemoglobin (oxyhemoglobin) and is produced by the oxidation of the normal ferrous iron contained in the heme part of hemoglobin to ferric iron which, in firm union with water, is chemically useless for respiration. The presence of methemoglobin in the blood is termed methemoglobinemia. It may be acquired anytime in life by exposure to a number of different chemical agents, such as nitrites or it may be congenital due a genetic condition: {{}}Hb M disease — the production of any one of a group of mutant hemoglobins known collectively as hemoglobin M ("M" for methemoglobin), or Deficiency of the enzyme methemoglobin reductase which is required for the reduction of methemoglobin to normal oxyhemoglobin. In both kinds of congenital methemoglobinemia, the cyanosis starts in early infancy with no history of lung or heart disease to account for it. However, the patterns of inheritance deficiency are distinctively different — autosomal dominant with Hb M disease versus autosomal recessive with the enzyme deficiency. The cyanosis from Hb M disease is resistant to treatment with reducing agents such as ascorbic acid or methylene blue, whereas with deficiency of the enzyme, the cyanosis is typically improved by ascorbic acid or methylene blue therapy.

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A transformation product of oxyhemoglobin because of the oxidation of the normal Fe²⁺ to Fe³⁺, thus converting ferroprotoporphyrin to ferriprotoporphyrin; it contains water in firm union with ferric iron, thus being chemically different from oxyhemoglobin and useless for respiration; found in sanguineous effusions and in the circulating blood after poisoning with acetanilid, potassium chlorate, and other substances. SYN: ferrihemoglobin.

- m. reductase a flavoenzyme catalyzing the reduction of m. to hemoglobin in the red blood cell.

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met·he·mo·glo·bin or chiefly Brit met·hae·mo·glo·bin (')met-'hē-mə-.glō-bən n a soluble brown crystalline basic blood pigment that is found in normal blood in much smaller amounts than hemoglobin, that is formed from blood, hemoglobin, or oxyhemoglobin by oxidation, and that differs from hemoglobin in containing ferric iron and in being unable to combine reversibly with molecular oxygen called also ferrihemoglobin

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met·he·mo·glo·bin (met-heґmo-glo″bin) [met- + hemoglobin] a brown pigment formed from hemoglobin by oxidation of the ferrous to the ferric state with essentially ionic bonds. A small amount is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier.