A peculiar infiltration of retroperitoneal tissue by lipid macrophages, occurring most commonly in women.
- juvenile x. single or multiple reddish to yellow papules or nodules, usually found in young children, consisting of dermal infiltration by histiocytes and Touton giant cells, with increasing fibrosis. SYN: nevoxanthoendothelioma.
- necrobiotic x. a cutaneous and subcutaneous x. with focal necrosis, presenting as multiple large, sometimes ulcerated, red to yellow granulomatous nodules with giant cells (often around the eyes) associated with paraproteinemia (usually monoclonal gammopathy).

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xan·tho·gran·u·lo·ma (zan″tho-gran″u-loґmə) [xanthoma + granuloma] a tumor having the histologic characteristics of both granuloma and xanthoma.

Medical dictionary. 2011.

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