Refers to nucleic acid base sequences proceeding the opposite direction from expression.

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up·stream 'əp-'strēm adv or adj in a direction along a molecule of DNA or RNA opposite to that in which transcription and translation take place and toward the end having a phosphate group attached to the position labeled 5' in the terminal nucleotide <a small coding sequence is located just \upstream from each...gene (J. N. Goldman )(et al)> compare DOWNSTREAM

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up·stream (upґstrēm) in molecular biology, a term used to denote a region of nucleic acid to the 5ґ side of a gene or region of interest.

Medical dictionary. 2011.

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