An antineoplastic agent and antiprotozoal orphan drug used in the treatment of Pneumocystis carinii pneumonia in AIDS patients.

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tri·me·trex·ate .trī-mi-'trek-.sāt n a toxic drug structurally related to methotrexate that is administered in the form of its glucuronate C19H23N5O3·C6H10O7 with concomitant administration of leucovorin to reduce toxicity and is used esp. in the treatment of Pneumocystis carinii pneumonia and certain carcinomas

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tri·me·trex·ate (tri″mə-trekґsāt) a folic acid antagonist structurally related to methotrexate; it competitively inhibits dihydrofolate reductase. Used investigationally as an antineoplastic; also used in combination with leucovorin to treat pneumocystis pneumonia in acquired immunodeficiency syndrome, administered intravenously as the glucuronate salt.

Medical dictionary. 2011.

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