thalidomide

thalidomide
A hypnotic drug which, if taken in early pregnancy, may cause the birth of infants with phocomelia and other defects; under investigational use for treatment of leprosy and as an immunomodulator in HIV infections and graft vs. host reactions.

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tha·lid·o·mide thə-'lid-ə-.mīd, -məd n a sedative, hypnotic, and antiemetic drug C13H10N2O4 that was used chiefly in Europe during the late 1950s and early 1960s esp. to treat morning sickness but was soon withdrawn after being shown to cause serious malformations (as missing or severely shortened arms and legs) in infants born to mothers using it during the first trimester of pregnancy and has now been reintroduced for use as a treatment for the cutaneous complications of leprosy and is being investigated for use as an immunomodulatory, anti-inflammatory, and antiangiogenic agent in the treatment of various diseases

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n.
a drug that was formerly used as a sedative. If taken during the first three months of pregnancy, it was found to cause fetal abnormalities involving limb malformation and was withdrawn as a sedative in 1962 . Recently, however, thalidomide has been found to be effective in treating certain cancers and other disorders (including Behçet's syndrome).

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tha·lid·o·mide (thə-lidґo-mīd) [USP] a sedative and hypnotic commonly used in Europe in the late 1950's and 1960's. Its use was discontinued because it was discovered to cause serious congenital anomalies in the fetus, notably amelia and phocomelia, when taken by a woman during early pregnancy. It is currently used in the treatment of erythema nodosum leprosum.

Medical dictionary. 2011.

Look at other dictionaries:

  • Thalidomide — Général Nom IUPAC 2 (2,6 Dioxopipéridin 3 yl)isoindol 1,3 dione No CA …   Wikipédia en Français

  • thalidomide — [ talidɔmid ] n. f. • v. 1960; de (acide N ph)thal(y glutamique), ide et imide, de amide ♦ Méd. Tranquillisant qui s est révélé tératogène (v. 1961). ● thalidomide nom féminin Médicament utilisé pour ses propriétés anti inflammatoires et… …   Encyclopédie Universelle

  • Thalidomide — 1958, from phthalimidoglutarimide, based on abbreviated form of naphthalene; a morning sickness drug responsible for severe birth defects in Europe from 1956 to 1961, when it was withdrawn. It was never approved for use in America thanks to the… …   Etymology dictionary

  • thalidomide — ► NOUN ▪ a drug formerly used as a sedative, but found to cause malformation of the fetus when taken in early pregnancy …   English terms dictionary

  • thalidomide — [thə lid′ə mīd΄] n. [< THALLIC + (IM)IDO + (glutari)mide < GLUT(EN) + (TART)AR(IC) + IMIDE] a crystalline solid, C13H10N2O4, formerly used as a sedative and hypnotic: found to be responsible for severe birth deformities when taken during… …   English World dictionary

  • Thalidomide — This article is about the drug. For the musical about a person with thalidomide disability, see Thalidomide!! A Musical. Thalidomide Systematic (IUPAC) name (RS) 2 (2,6 dioxopiperidin 3 yl) 1H isoind …   Wikipedia

  • Thalidomide — Талидомид (Thalidomide) Химическое соединение …   Википедия

  • thalidomide — /theuh lid euh muyd /, n. a crystalline, slightly water soluble solid, C13H10N2O4, formerly used as a sedative: if taken during pregnancy, it may cause severe abnormalities in the limbs of the fetus. [1955 60; (ph)thal(im)ido(glutari)mide =… …   Universalium

  • thalidomide — [[t]θəlɪ̱dəma͟ɪd[/t]] 1) N UNCOUNT Thalidomide is a drug which used to be given to pregnant women, before it was discovered that it resulted in babies being born with wrongly shaped arms and legs. 2) ADJ: ADJ n Thalidomide is used to describe… …   English dictionary

  • thalidomide — n. a drug formerly used as a sedative but found in 1961 to cause foetal malformation when taken by a mother early in pregnancy. Phrases and idioms: thalidomide baby (or child) a baby or child born deformed from the effects of thalidomide.… …   Useful english dictionary

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