streptokinase

streptokinase
An extracellular metalloenzyme from hemolytic streptococci that cleaves plasminogen, producing plasmin, which causes the liquefaction of fibrin (same activity as staphylokinase and urokinase); thus, used in the removal of clots. SYN: plasminokinase, streptococcal fibrinolysin.

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strep·to·ki·nase .strep-tō-'kī-.nās, -.nāz n a proteolytic enzyme produced by hemolytic streptococci that promotes the dissolution of blood clots by activating plasminogen to produce plasmin see VARIDASE

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n.
an enzyme produced by some haemolytic bacteria of the genus Streptococcus that is capable of liquefying blood clots (see also fibrinolytic). It is injected to treat blockage of blood vessels, including deep vein thrombosis, infarction, and pulmonary embolism. Side-effects may include digestive upsets, haemorrhage, and fever. It is also used in combination with streptodornase, applied topically, to remove slough and blood clot and thus promote healing of ulcers. Trade names: Kabikinase, Streptase, Varidase Topical.

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strep·to·ki·nase (SK) (strep″to-kiґnās) [streptococcus + kinase] a protein produced by β-hemolytic streptococci; although it has no intrinsic enzymatic activity, it binds plasminogen and causes cleavage of that molecule to plasmin. It is used as a thrombolytic agent in the treatment of acute coronary arterial thrombosis, acute pulmonary embolism, deep vein thrombosis, and acute arterial thromboembolism or thrombosis, administered intravenously. It is also used to clear obstructed arteriovenous cannulae.

Medical dictionary. 2011.

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  • Streptokinase — C Streptokinase C (gelb) und D (grün) mit Plasmin (blau) nach PDB  …   Deutsch Wikipedia

  • streptokinase — ● streptokinase nom féminin Enzyme sécrétée par les streptocoques des groupes A, C et G. streptokinase [stʀɛptokinɑz] n. f. ÉTYM. 1953, in Larousse; de 2. strepto , et kinase. ❖ ♦ Méd. Enzyme extraite de cultures de str …   Encyclopédie Universelle

  • streptokinase — [strep΄təkī′nās, strep΄təkin′ās] n. [< STREPTOCOCCUS + KINASE] a proteolytic enzyme derived from certain hemolytic streptococci, used in dissolving blood clots …   English World dictionary

  • Streptokinase — drugbox IUPAC name = Streptococci streptokinase CAS number = 9002 01 1 ATC prefix = B01 ATC suffix = AD01 ATC supplemental = ATC|B06|AA55 PubChem = DrugBank = BTD00028 chemical formula = C2100H3278N566O669S4 molecular weight = 47286.7 g/mol… …   Wikipedia

  • Streptokinase — Strep|to|ki|na|se [↑ Strepto (2) u. ↑ Kinase] aus Streptokokken isoliertes, Plasminogen enzymartig aktivierendes Protein (MG 47 408, 415 Aminosäuren), das in der Thrombose , Embolie u. Herzinfarkttherapie zur Auflösung von Blutgerinnseln… …   Universal-Lexikon

  • Streptokinase — СТРЕПТОКИНАЗА ( Streptokinase )*. Ферментный препарат, получаемый из культуры b гемолитического стрептококка группы С. Выпускается за рубежом под названиями Авелизин (Аwelysin) [Название препарата фирмы АWD (Аrzneimittelwerk Dresden GmbH… …   Словарь медицинских препаратов

  • streptokinase — noun Date: 1944 a proteolytic enzyme produced by hemolytic streptococci that promotes the dissolution of blood clots by activating plasminogen to produce plasmin …   New Collegiate Dictionary

  • streptokinase — Plasminogen activator released by Streptococcus pyogenes. Occurs in two forms, A and B …   Dictionary of molecular biology

  • streptokinase — /strep toh kuy nays, nayz, kin ays, ayz/, n. Pharm. an enzyme used to dissolve blood clots. [1945 50; STREPTO + KINASE] * * * …   Universalium

  • streptokinase — noun Any of a class of enzymes that catalyzes the conversion of plasminogen to plasmin and are used to dissolve blood clots …   Wiktionary

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