Keratitis-ichthyosis-deafness syndrome

An inherited disorder in which affected persons have: {{}}Keratitis — gradual destruction of the cornea of the eye, sometimes leading to blindness Ichthyosis — localized areas of disfiguring reddish thickened skin ("fish skin") Deafness — at birth Another characteristic feature is thin or even absent scalp hair. Some patients have developed carcinoma of the tongue while others have subtle abnormalities of the nervous system. The KID syndrome is inherited as an autosomal dominant trait. The cause of the syndrome is mutation in the connexin-26 gene (which is located on chromosome 13). The disease is also called the KID syndrome, an acronym

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a rare syndrome, often inherited in autosomal recessive fashion, consisting of erythroderma, lamellar ichthyosis, sensorineural hearing loss, and sometimes keratitis, inflammatory corneal vascularization, postnatal growth deficiency, alopecia, nail dystrophy, tooth malformations, and decreased sweating. Called also KID s. and Senter s.