somatomedin

somatomedin
S. A is a peptide (MW about 4,000), synthesized in the liver and probably in the kidney, that is capable of stimulating certain anabolic processes in bone and cartilage, such as synthesis of DNA, RNA, and protein (including chondromucoprotein), and the sulfation of mucopolysaccharides; secretion and/or biological activity of s. is known to be dependent on somatotropin. SEE ALSO: insulinlike growth factor. [somato, tropin + mediator + -in]

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so·ma·to·me·din sō-.mat-ə-'mēd-ən, .sō-mət-ə- n any of several endogenous peptides produced esp. in the liver that are dependent on and prob. mediate growth hormone activity (as in sulfate uptake by epiphyseal cartilage)

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n.
a protein hormone, produced by the liver in response to stimulation by growth hormone, that stimulates protein synthesis and promotes growth. It is biochemically similar to insulin and has some actions similar to insulin; it is therefore sometimes said to have insulin-like activity (ILA) or is referred to as insulin-like growth factor (IGF).

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so·ma·to·me·din (so″mə-to-meґdin) any of several peptides formed in the liver and other tissues and found in plasma, complexed with transport proteins; they stimulate cellular growth and replication, particularly in bone and muscle, as second messengers in the somatotropic actions of growth hormone and also have insulin-like biological activities. Two such peptides have been isolated, insulinlike growth factors I and II (see under factor).

Medical dictionary. 2011.

Look at other dictionaries:

  • Somatomedin — is a group of hormones that is produced, when stimulated by somatotropin (STH), to promote cell growth and division [eMedicineDictionary|Somatomedin] . In this way, they mediate the effect of somatotropin (also known as growth hormone… …   Wikipedia

  • somatomedin — [sə mat΄ə mēd′ən, sō΄mə təmēd′ən] n. any of a group of protein hormones produced in the liver and regulating the activity of growth hormones in building muscle and cartilage …   English World dictionary

  • somatomedin — Generic term for insulin like growth factors (IGFs) produced in the liver and released in response to somatotropin. Somatomedins stimulate the growth of bone and muscle, and also influence calcium, phosphate, carbohydrate and lipid metabolism.… …   Dictionary of molecular biology

  • somatomedin — noun Etymology: somat + intermediary + 1 in Date: 1971 any of several endogenous peptides produced especially in the liver that are dependent on and probably mediate growth hormone activity (as in sulfate uptake by epiphyseal cartilage) …   New Collegiate Dictionary

  • somatomedin — /seuh mat euh meed n, soh meuh teuh /, n. Biochem. any of various liver hormones that enhance the activity of a variety of other hormones, as somatotropin. [1970 75; SOMATO or SOMATO(TROPIN) + med , as in INTERMEDIARY + IN2] * * * …   Universalium

  • somatomedin — noun Any of a group of peptides which mediate the action of somatotropin on cartilage …   Wiktionary

  • Somatomedin — So|ma|to|me|din [Kurzw. aus ↑ Somatotropin u. ↑ intermediär], das; s, e; Abk.: SM; Syn.: Insulin like Growth Factor (ILGF, IGF), Non suppressible Insulin like Activity (NSILA), Sulfation Factor ( …   Universal-Lexikon

  • somatomedin A — former name for insulinlike growth factor II …   Medical dictionary

  • somatomedin C — former name for insulinlike growth factor I …   Medical dictionary

  • Somatomedin — Somato|medi̱n [Kurzbildung zu ↑Somatotropin u. ↑intermediär] s; s, e: unter dem Einfluß von Wachstumshormon in der Leber gebildete und freigesetzte Substanz, durch die das Wachstumshormon wirksam wird …   Das Wörterbuch medizinischer Fachausdrücke

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