Thickening and induration of the skin caused by new collagen formation, with atrophy of pilosebaceous follicles; either a manifestation of progressive systemic sclerosis or localized (morphea). See systemic sclerosis, morphea. SYN: systemic s., systemic sclerosis (2). [sclero- + G. derma, skin]
- linear s. localized s. with band-like lesions of skin with induration, atrophy, hyper- or hypopigmentation, which may be disfiguring with extension into underlying tissues and joint contractures. Involvement of the forehead and scalp has been called coup de sabre (q.v.). SYN: morphea linearis.
- localized s. SYN: morphea.
- systemic s. SYN: s..

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sclero·der·ma .skler-ə-'dər-mə n, pl -mas or -ma·ta -mət-ə a usu. slowly progressive disease marked by the deposition of fibrous connective tissue in the skin and often in internal organs and structures, by hand and foot pain upon exposure to cold, and by tightening and thickening of the skin called also dermatosclerosis

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thickening of the skin, either localized (see morphoea) or generalized, resulting in waxy ivory-coloured areas. Treatment is unsatisfactory, but spontaneous resolution may occur. The cause is unknown, but scleroderma may well be an autoimmune disease. systemic sclerosis is a related multisystem disorder, which may occur as part of the CREST syndrome.

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scle·ro·der·ma (sklēr″o-durґmə) [sclero- + derma] 1. chronic hardening and thickening of the skin, a finding in various different diseases; there are two primary forms: localized scleroderma and 2. systemic scleroderma. Called also dermatosclerosis. systemic s.

Medical dictionary. 2011.

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Look at other dictionaries:

  • Scleroderma — Scleroderma …   Wikipédia en Français

  • Scleroderma — Scler o*der ma, n. [NL.] (Med.) A disease of adults, characterized by a diffuse rigidity and hardness of the skin. [1913 Webster] …   The Collaborative International Dictionary of English

  • scleroderma — scleroderma. См. склеродермия. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Scleroderma — Scleroderma, 1) (S. Pers., N. v. E.), Pilzgattung aus der Familie der Gasteromycetes Trichogastri; Art: S. vulgare, bildet eine harte, warzige, unregelmäßig aufreißende, etwas gestielte Blase, ist etwa 2 Zoll dick, citronengelb, mit kleinen… …   Pierer's Universal-Lexikon

  • Scleroderma — Pers. (Fellstreuling, Hart , Kartoffelbovist), Pilzgattung aus der Ordnung der Gastromyzeten, auf der Erde oder halb unterirdisch wachsende, mit wurzelartigen Myceliumsträngen versehene, ziemlich große, knollenförmige Pilze mit dicker, leder bis… …   Meyers Großes Konversations-Lexikon

  • Sclerodérma — Pers., Hartbofist, Pilzgattg. der Gasteromyzeten, mit hühnereigroßen, fast ganz unterirdischen, trüffelartigen Fruchtkörpern; S. vulgāris Fr. wird häufig als echte Trüffel verkauft, ist aber giftig …   Kleines Konversations-Lexikon

  • scleroderma — 1866, from Mod.L., from Gk. skleros hard (see SCLEROSIS (Cf. sclerosis)) + derma skin (see DERMA (Cf. derma)) …   Etymology dictionary

  • scleroderma — [sklir΄ə dʉr′mə, skler΄dʉr′mə] n. [ModL: see SCLERO & DERMA1] 1. hardening and thickening of the skin due to abnormal fibrous tissue growth 2. a disease in which this condition occurs …   English World dictionary

  • Scleroderma — This article is about the disease. For the mushroom, see Scleroderma (genus). Not to be confused with the skin disease scleredema. Scleroderma Classification and external resources ICD 10 L …   Wikipedia

  • scleroderma — /sklear euh derr meuh, skler /, n. Pathol. a disease in which connective tissue anywhere in the body becomes hardened and rigid. [1865 70; SCLERO + DERMA] * * * or progressive systemic sclerosis Chronic disease that hardens the skin and fixes it… …   Universalium

  • Scleroderma — Scleroderma …   Wikipédia en Français

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