sarcoidosis

A systemic granulomatous disease of unknown cause, especially involving the lungs with resulting interstitial fibrosis, but also involving lymph node s, skin, liver, spleen, eyes, phalangeal bones, and parotid glands; granulomas are composed of epithelioid and multinucleated giant cells with little or no necrosis. SYN: Besnier-Boeck-Schaumann disease, Besnier-Boeck-Schaumann syndrome, Boeck disease, Boeck sarcoid, sarcoid, Schaumann syndrome. [sarcoid + G. -osis, condition]

- hypercalcemic s. s. with hypercalcemia of unknown cause, not necessarily associated with detectable bone involvement by s..

* * *

sar·coid·o·sis .sär-.kȯid-'ō-səs n, pl -o·ses -.sēz a chronic disease of unknown cause that is characterized by the formation of nodules resembling true tubercles esp. in the lymph nodes, lungs, bones, and skin called also Boeck's disease, Boeck's sarcoid, lupus pernio

* * *

n.

a chronic disorder of unknown cause in which the lymph nodes in many parts of the body are enlarged and small fleshy nodules (see granuloma) develop in the lungs, liver, and spleen. The skin, nervous system, eyes, and salivary glands are also commonly affected (see uveoparotitis), and the condition has features similar to tuberculosis. Recovery is complete with minimal after-effects in two-thirds of all cases.

* * *

sar·coi·do·sis (sahr″koi-doґsis) [sarcoid + -osis] a chronic, progressive, systemic granulomatous reticulosis of unknown etiology, characterized by hard tubercles (q.v.). It can affect almost any organ or tissue, including the skin, lungs, lymph nodes, liver, spleen, eyes, and small bones of the hands and feet. Laboratory findings may include hypercalcemia and hypergammaglobulinemia. There is usually low or absent reactivity to tuberculin, and in active cases the Kveim test is positive. Called also sarcoid, Besnier-Boeck disease, Boeck disease or sarcoid, and Schaumann disease, sarcoid, or syndrome.

Sarcoidosis. High resolution CT scan shows areas of conglomerate fibrosis in a perihilar distribution with associated bronchial distortion and volume loss.