saccharopine

saccharopine
A derivative of α-ketoglutarate and l-lysine that is an intermediate in l-lysine catabolism; elevated in cases of saccharopinuria.
- s. dehydrogenase two enzymes that are used in the pathway of l-lysine catabolism; the first isoform catalyzes the reversible conversion of l-lysine, α-ketoglutarate, and NADH to s. and NAD+; the other isoform reversibly catalyzes to conversion of s. and NAD+ to l-glutamate, NADH, and l-α-aminoadipate δ-semialdehyde. A deficiency of one of these isoforms is associated with familial hyperlysinemia and saccharopinuria.

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sac·cha·ro·pine (sakґə-ro-pēn″) an intermediate in the metabolism of lysine, formed by condensation of lysine and α-ketoglutarate; it accumulates abnormally in some disorders of lysine degradation.

Medical dictionary. 2011.

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  • Saccharopine dehydrogenase (NADP+, L-lysine-forming) — In enzymology, a saccharopine dehydrogenase (NADP+, L lysine forming) (EC number|1.5.1.8) is an enzyme that catalyzes the chemical reaction:N6 (L 1,3 dicarboxypropyl) L lysine + NADP+ + H2O ightleftharpoons L lysine + 2 oxoglutarate + NADPH +… …   Wikipedia

  • saccharopine dehydrogenase — sac·cha·ro·pine de·hy·dro·gen·ase (sakґə ro pēn″ de hiґdro jən ās) an enzyme activity that catalyzes oxidative cleavage of saccharopine to form α aminoadipate semialdehyde and glutamate, using NAD+ as an electron… …   Medical dictionary

  • saccharopine dehydrogenase (NAD+ L-glutamate-forming) — sac·cha·ro·pine de·hy·dro·gen·ase (NAD+, L glu·ta·mate form·ing) (sakґə ro pēn″ de hiґdro jən ās glooґtə māt formґing) [EC 1.5.1.9] official nomenclature for saccharopine dehydrogenase …   Medical dictionary

  • saccharopine dehydrogenase (NADP+ L-lysine-forming) — sac·cha·ro·pine de·hy·dro·gen·ase (NADP+, L ly·sine form·ing) (sakґə ro pēn″ de hiґdro jən ās liґsēn formґing) [EC 1.5.1.8] official nomenclature for lysine ketoglutarate reductase …   Medical dictionary

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