retinoic acid

retinoic acid
Vitamin A1 acid; retinal in which the terminal –CHO has been oxidized to a –COOH; used topically in the treatment of acne; plays an important role in growth and differentiation. SYN: vitamin A1 acid.
- 13-cis-r. the retinoid most used in the U.S. to treat acne; it works by reducing sebum secretion. Use in pregnancy is contraindicated because of teratogenicity.

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ret·i·no·ic acid .ret-ən-.ō-ik- n either of two isomers of an acid C20H28O2 derived from vitamin A and used esp. in the treatment of acne:
a) or all-trans-retinoic acid TRETINOIN
b) or 13-cis-retinoic acid ISOTRETINOIN

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ret·i·no·ic ac·id (ret″ĭ-noґik) an oxidized derivative of retinol, formed by carboxylation of the aldehyde group of retinal (q.v.). It is believed to be the form of vitamin A that plays a role in the development and growth of bone and in the maintenance of normal epithelial structures. In pharmacology, the term is often used alone to mean the all-trans isomer (tretinoin); the 13-cis isomer is usually called isotretinoin.

Medical dictionary. 2011.

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  • Retinoic acid — Ret in*o ic ac id, n. (Chem.) A retinoid compound ({C20H28O2}), closely related to vitamin A. It is also called {tretinoin} and {vitamin A acid}. [PJC] …   The Collaborative International Dictionary of English

  • retinoic acid — [ret΄ n ō′ik] n. a vitamin A derivative, C20H28O2, used in the treatment of acne, skin wrinkles, etc. * * * …   Universalium

  • retinoic acid — [ret΄ n ō′ik] n. a vitamin A derivative, C20H28O2, used in the treatment of acne, skin wrinkles, etc …   English World dictionary

  • Retinoic acid — For all trans retinoic acid as a drug, see Tretinoin. For 9 cis retinoic acid as a drug, see Alitretinoin. For 13 cis retinoic acid as a drug, see Isotretinoin. All trans retinoic acid …   Wikipedia

  • retinoic acid — (= vitamin A) The aldehyde (retinal) has long been known to be involved in photoreception, but retinoic acid has other roles. There are cytoplasmic retinoic acid binding proteins and retinoic acid response elements that regulate gene… …   Dictionary of molecular biology

  • retinoic acid — noun A derivative of vitamin A, used in the treatment of acne; it is essential for bone and tissue development. Syn: vitamin A acid See Also: all trans ret …   Wiktionary

  • retinoic acid — A form of vitamin A that is made by the body, and can also be made in the laboratory. It is used to treat acute promyelocytic leukemia, usually together with other drugs, and to treat acne. It is being studied in the treatment and prevention of… …   English dictionary of cancer terms

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