- A term originally used for a pressor substance obtained from rabbits' kidneys, now an enzyme that converts angiotensinogen to angiotensin I. SYN: angiotensinogenase.
* * *re·nin 'rē-nənalso 'ren-ən n a proteolytic enzyme of the blood that is produced and secreted by the juxtaglomerular cells of the kidney and hydrolyzes angiotensinogen to angiotensin I
* * *n.an enzyme released into the blood by the kidney in response to stress. It reacts with a substrate from the liver to produce angiotensin, which causes constriction of blood vessels and thus an increase in blood pressure. Excessive production of renin results in the syndrome of renal hypertension.
* * *re·nin (reґnin) [EC 126.96.36.199] an enzyme of the hydrolase class that catalyzes cleavage of the leucine-leucine bond in angiotensinogen to generate angiotensin I. The enzyme is synthesized as inactive prorenin in the kidney and released into the blood in the active form in response to various metabolic stimuli. See also renin-angiotensin-aldosterone system, under system. Not to be confused with rennin (chymosin).
Medical dictionary. 2011.