protooncogene

protooncogene
A gene conserved long on the evolutionary scale present in the normal human genome, that appears to have a role in normal cellular physiology and is often involved in regulation of normal cell growth or proliferation; as a result of somatic mutations, these genes may become oncogenic; products of proto-oncognes may have important roles in normal cellular differentiation.

Medical dictionary. 2011.

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  • protooncogene — noun A gene that promotes the specialization and division of normal cells; it can become mutated to form an oncogene …   Wiktionary

  • protooncogene — pro·to·on·co·gè·ne s.m. TS biol. gene che, per intervento di diversi fattori, si trasforma in oncogene {{line}} {{/line}} DATA: sec. XX. ETIMO: comp. di proto e oncogene …   Dizionario italiano

  • protooncogene — pl.m. protooncogeni …   Dizionario dei sinonimi e contrari

  • Протоонкоген (Protooncogene) — ген в нормальной клетке, имеющий структуру, идентичную генам некоторых вирусов. Некоторые из таких генов являются важными регуляторами процесса деления клеток, а их повреждение может привести к перерождению этих генов в онкогены. Источник:… …   Медицинские термины

  • ПРОТООНКОГЕН — (protooncogene) ген в нормальной клетке, имеющий структуру, идентичную генам некоторых вирусов. Некоторые из таких генов являются важными регуляторами процесса деления клеток, а их повреждение может привести к перерождению этих генов в онкогены …   Толковый словарь по медицине

  • oncogene — 1. Any of a family of genes that normally encode proteins involved in cell growth or regulation (e.g., protein kinases, GTPases, nuclear proteins, growth factors) but that may foster malignant processes if mutated or activated by contact with… …   Medical dictionary

  • Alpha-enolase — Enolase 1, (alpha) Rendering based on PDB 2PSN …   Wikipedia

  • CBFB — Core binding factor, beta subunit, also known as CBFB, is a human gene. PBB Summary section title = summary text = The protein encoded by this gene is the beta subunit of a heterodimeric core binding transcription factor belonging to the… …   Wikipedia

  • VAV1 — Vav 1 oncogene, also known as VAV1, is a human gene. PBB Summary section title = summary text = The protein encoded by this proto oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP… …   Wikipedia

  • FGR (gene) — Gardner Rasheed feline sarcoma viral (v fgr) oncogene homolog, also known as FGR, is a human gene.cite web | title = Entrez Gene: FGR Gardner Rasheed feline sarcoma viral (v fgr) oncogene homolog| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db …   Wikipedia

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