properdin

properdin
A globulin in normal serum involved in resistance to infection that participates, in conjunction with other factors, in an alternative pathway to the activation of the terminal components of complement; a deficiency of p. results in the lack of stabilization of the alternative C3-convertase enzyme (an X-linked recessive disorder). SEE ALSO: p. system, component of complement, factor P. [pro- + L. perdo, to destroy]

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pro·per·din prō-'pərd-ən n a blood serum protein that participates in the activation of complement in a pathway which does not involve the presence of antibodies

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n.
a group of substances in blood plasma that, in combination with complement and magnesium ions, is capable of destroying certain bacteria and viruses. The properdin complex occurs naturally, rather than as the result of previous exposure to microorganisms, and its activity is not directed against any particular species. Compare antibody.

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pro·per·din (proґpər-din) a nonimmunoglobulin gamma globulin component of the alternative pathway of complement activation; it complexes with C3b and stabilizes alternative pathway C3 and C5 convertases (C3bBb and C3bnBb). Called also factor P.

Medical dictionary. 2011.

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  • Properdin —   [Kurzwort] das, s, ein aus vier Untereinheiten bestehendes Serumprotein, das mit Insulin u. a. unlöslichen Polysacchariden Komplexe bildet, die das Komplement, ein Funktionssystem des Blutserums, aktivieren; Properdin ist somit an der… …   Universal-Lexikon

  • properdin — properdin. См. пропердин. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • properdin — ☆ properdin [prō pʉrd′ n ] n. 〚/span> PRO(TEIN) + L perdere, to destroy + IN1〛 a protein present in blood serum and active in the destruction of bacteria and the neutralization of viruses * * * pro·per·din (prō pûrʹdn) n. A protein in …   Universalium

  • properdin — ☆ properdin [prō pʉrd′ n ] n. [< PRO(TEIN) + L perdere, to destroy + IN1] a protein present in blood serum and active in the destruction of bacteria and the neutralization of viruses …   English World dictionary

  • Properdin — protein Name = complement factor properdin caption = width = HGNCid = 8864 Symbol = CFP AltSymbols = PFC EntrezGene = 5199 OMIM = 300383 RefSeq = NM 002621 UniProt = P27918 PDB = ECnumber = Chromosome = X Arm = p Band = 11.4… …   Wikipedia

  • properdin — n. a group of substances in blood plasma that, in combination with complement and magnesium ions, is capable of destroying certain bacteria and viruses. The properdin complex occurs naturally, rather than as the result of previous exposure to… …   The new mediacal dictionary

  • Properdin deficiency — Infobox Disease Name = PAGENAME Caption = DiseasesDB = ICD10 = ICD9 = ICDO = OMIM = 312060 MedlinePlus = eMedicineSubj = eMedicineTopic = MeshID =Properdin deficiency is a rare X linked disease in which properdin, an important complement factor,… …   Wikipedia

  • properdin — noun Etymology: probably from 1pro + Latin perdere to destroy + English 1 in more at perdition Date: 1954 a blood serum protein that participates in the activation of complement in a pathway which does not involve the presence of antibodies …   New Collegiate Dictionary

  • properdin — (= Factor P) Component of the alternative pathway for complement activation: complexes with C3b and stabilizes the alternative pathway C3 convertase (C3bBbP) that cleaves C3 …   Dictionary of molecular biology

  • properdin — noun A protein in human serum that complements part of the immune system …   Wiktionary

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