prodrug

prodrug
A class of drugs, the pharmacologic action of which results from conversion by metabolic processes within the body (biotransformation).

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pro·drug 'prō-.drəg n a pharmacologically inactive substance that is the modified form of a pharmacologically active drug to which it is converted (as by enzymatic action) in the body <\prodrugs that enhance drug absorption> <a \prodrug that is rapidly converted to phenytoin in the body (Danielle G. LeStrange)>

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pro·drug (proґdrugґ) [pro- + drug] a compound that, on administration, must undergo chemical conversion by metabolic processes before becoming an active pharmacological agent; a precursor of a drug.

Medical dictionary. 2011.

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  • Prodrug — A prodrug is a pharmacological substance (drug) administered in an inactive (or significantly less active) form. Once administered, the prodrug is metabolised in vivo into an active metabolite, a process termed bioactivation. The rationale behind …   Wikipedia

  • Prodrug — Als Prodrug (das oder die Prodrug[1]) wird ein inaktiver oder wenig aktiver pharmakologischer Stoff bezeichnet, der erst durch Verstoffwechselung (Metabolisierung) im Organismus in einen aktiven Wirkstoff (Metaboliten) überführt wird. Prodrugs… …   Deutsch Wikipedia

  • prodrug — /proh drug /, n. Pharm. an inactive substance that is converted to a drug within the body by the action of enzymes or other chemicals. [PRO 1 + DRUG] * * * …   Universalium

  • prodrug — noun A drug that is administered in an inactive form that is metabolised in the body into a biologically active compound …   Wiktionary

  • Prodrug — Pro|drug 〈[ drʌg] f. 10; Pharm.〉 Arzneistoff, der als Vorstufe verabreicht u. im Organismus allmählich enzymatisch in einen Wirkstoff transformiert wird, Langzeitpräparat [<Pro... + engl. drug „Medikament, Droge“] * * * Pro|drug, Pro Drug [… …   Universal-Lexikon

  • Prodrug — Pro|drug 〈[ drʌg] f.; Gen.: , Pl.: s; Pharm.〉 Arzneistoff, der als Vorstufe verabreicht u. im Organismus allmählich enzymat. in einen Wirkstoff transformiert wird, Langzeitpräparat [Etym.: <Pro…+ engl. drug »Medikament, Droge«] …   Lexikalische Deutsches Wörterbuch

  • Prodrug — Pro|drug [ pro:drʌg] das od. die; [s], s <zu ↑pro... u. engl. drug »Droge, Arzneimittel«> Substanz, die selbst biologisch weitgehend inaktiv ist, aber im Organismus enzymatisch od. nicht enzymatisch in eine aktive Form umgewandelt wird (Med …   Das große Fremdwörterbuch

  • prodrug — noun a biologically inactive compound which can be metabolized in the body to produce a drug …   English new terms dictionary

  • prodrug — n. a drug that requires metabolism in the liver before becoming biologically active. Examples are carbimazole, which is metabolized to the pharmacologically active compound methimazole; and capecitabine, which is metabolized to fluorouracil …   The new mediacal dictionary

  • prodrug — pro•drug [[t]ˈproʊˌdrʌg[/t]] n. pha an inactive substance that is converted to a drug within the body by the action of enzymes or other chemicals …   From formal English to slang

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