porokeratosis

porokeratosis
A rare dermatosis in which there is a thickening of the stratum corneum with an annular keratotic rim or cornoid lamella surrounding progressive centrifugal atrophy; cutaneous carcinoma has been reported to arise in the lesions. SYN: Mibelli disease. [G. poros, pore, + keratosis]
- actinic p. a lesion that occurs on exposed areas of extremities primarily; bears a resemblance to actinic keratosis, but the histologic features are those of p..

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po·ro·ker·a·to·sis -.ker-ə-'tō-səs n any of several uncommon inherited skin disorders characterized by hypertrophy of the stratum corneum

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po·ro·ker·a·to·sis (por″o-ker″ə-toґsis) [poro-2 + keratosis] any of several chronic, progressive disorders of keratinization, seen most often in light-skinned persons. The characteristic lesion is round and craterlike with an atrophic center and an elevated, thick, keratotic border formed by a cornoid lamella; lesions may enlarge into circinate, serpiginous, or gyrate forms. Lesions can be premalignant, progressing to basal cell carcinoma or squamous cell carcinoma. It is sometimes inherited as an autosomal dominant disorder, but most cases are sporadic, and a number of factors, including ultraviolet exposure, infection, and immunosuppression, may be involved in its pathogenesis. porokeratotic adj

Medical dictionary. 2011.

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  • porokeratosis punctata palmaris et plantaris — punctate porokeratosis a skin disorder affecting the palms and soles and occurring during or after adolescence, characterized by tiny keratotic plugs that have elevated margins and do not enlarge; patients often exhibit either linear or Mibelli… …   Medical dictionary

  • porokeratosis of Mibelli — the classic type of porokeratosis, a chronic, progressive, autosomal dominant type seen most often in males, usually first appearing in early childhood. Lesions are isolated, light brown papules with irregular shapes and a surrounding ridge that… …   Medical dictionary

  • porokeratosis palmaris et plantaris disseminata — a variant of punctate porokeratosis characterized by small, superficial, slightly discolored lesions on the soles or palms or both, with gyrate or annular shapes; there may be hundreds of lesions, and they may later appear elsewhere on the body …   Medical dictionary

  • porokeratosis ptychotropica — a rare verrucous variant of porokeratosis, affecting the gluteal cleft and characterized by pruritic, confluent plaques in the perianal region that extend symmetrically to the buttocks …   Medical dictionary

  • porokeratosis — …   Useful english dictionary

  • Plaque-type porokeratosis — Classification and external resources OMIM 175800 DiseasesDB 32454 MeSH …   Wikipedia

  • Disseminated superficial actinic porokeratosis — Classification and external resources A porokeratosis lesion in a patient with disseminated superficial actinic porokeratosis. OMIM …   Wikipedia

  • Disseminated superficial porokeratosis — is a more generalized processes than porokeratosis Mibelli, and involves mainly the exptremities in a bilateral, symmetric fashion.[1]:533 In about 50% of cases, skin lesions only develop in sun exposed areas, and this is referred to as… …   Wikipedia

  • Craniosynostosis–anal anomalies–porokeratosis syndrome — Classification and external resources OMIM 603116 Craniosynostosis–anal anomalies–porokeratosis syndrome (also known as CAP syndrome ) is a cutaneous condition inherited in an autosomal recessive fashion.[1] …   Wikipedia

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