1. Enzymes catalyzing the hydrolysis of polynucleotides to oligonucleotides or to mononucleotides; e.g., phosphodiesterases, nucleases. 2. Terms once applied to the two polynucleotide phosphatases, 2′(3′)- and 5′-, which do not cleave internucleotide links.

Medical dictionary. 2011.

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