An alkaloid of physostigma; it is a reversible inhibitor of the cholinesterases, and prevents destruction of acetylcholine; used as a cholinergic agent, and experimentally to enhance the action of acetylcholine at any of its sites of liberation. SYN: eserine.
- p. salicylate used by conjunctival instillation to reduce tension in glaucoma, in the treatment of postoperative intestinal atony and urinary retention, in the management of myasthenia gravis, and to counteract excessive doses of tubocurarine; also available as p. sulfate, with the same uses. SYN: eserine salicylate.

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phy·so·stig·mine .fī-sə-'stig-.mēn n a tasteless crystalline alkaloid with anticholinesterase activity that is obtained from Calabar beans and is used parenterally in the form of its salicylate C15H21N3O2·C7H6O3 esp. to reverse the toxic effects of an anticholinergic agent (as atropine) and topically in the form of its sulfate (C15H21N3O2)2·H2SO3 as a miotic in the treatment of glaucoma called also eserine

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phy·so·stig·mine (fi″zo-stigґmēn) [USP] a cholinergic alkaloid having anticholinesterase activity and obtained from the dried ripe seed (Calabar bean) of Physostigma venenosum; used topically to produce miosis and decrease of intraocular pressure in glaucoma and parenterally to reverse the central nervous system effects produced by overdosage of anticholinergic drugs (anticholinergic syndrome). Called also eserine.

Medical dictionary. 2011.

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Look at other dictionaries:

  • Physostigmine — Structure de la physostigmine Général Nom IUPAC ((3aR,8aS) 1,3a,8 t …   Wikipédia en Français

  • Physostigmine — Phy so*stig mine, n. (Chem.) An alkaloid found in the Calabar bean (the seed of {Physostigma venenosum}), and extracted as a white, tasteless, substance, amorphous or crystalline; formerly called {eserine}, with which it was regarded as identical …   The Collaborative International Dictionary of English

  • physostigmine — [fī΄sō stig′mēn΄, fī΄sō stig′min] n. [< ModL Physostigma, name of the genus including the Calabar bean < Gr physa, a bellows (< IE * phus , var. of * pu , *phu , to blow > L pustula) + stigma, a prick (see STICK) + INE3] a colorless… …   English World dictionary

  • Physostigmine — drugbox IUPAC name = [(3aR,8bS) 3,4,8b Trimethyl 2,3a dihydro 1 H pyrrolo [2,3 b] indol 7 yl] N methylcarbamate CAS number = 57 47 6 ATC prefix = S01 ATC suffix = EB05 ATC supplemental = ATC|V03|AB19 PubChem = 5983 DrugBank = APRD00406 C=15 |… …   Wikipedia

  • physostigmine — physostigma [ fizostigma ] n. m. • 1873; du gr. phusa « vésicule » et stigma « stigmate » ♦ Bot. Plante (légumineuses papilionacées) exotique, herbacée, communément appelée fève de Calabar, dont les graines renferment un alcaloïde vénéneux, la… …   Encyclopédie Universelle

  • physostigmine salicylate — [USP] the salicylate salt of physostigmine with the same properties as the alkaloid …   Medical dictionary

  • physostigmine sulfate — [USP] the sulfate salt of physostigmine with the same properties as the alkaloid …   Medical dictionary

  • physostigmine — noun Etymology: International Scientific Vocabulary, from New Latin Physostigma, genus of vines that bear the Calabar bean Date: 1864 a crystalline tasteless alkaloid C15H21N3O2 from the Calabar bean that is used in medicine especially in the… …   New Collegiate Dictionary

  • physostigmine — /fuy soh stig meen, min/, n. Pharm. an alkaloid, C15H21N3O2, used in the treatment of Alzheimer s disease to raise the level of the neurotransmitter acetylcholine and also as a miotic in glaucoma. [1860 65; < NL Physostigm(a) genus of plants… …   Universalium

  • physostigmine — noun A parasympathomimetic, a reversible cholinesterase inhibitor alkaloid of the Calabar bean, used to treat certain medical conditions …   Wiktionary

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