phosphoribosyltransferase
- phosphoribosyltransferase
One of a
group of enzymes (EC 2.4.2.x, pentosyltransferases) that transfers d-ribose 5-phosphate from 5-phospho-α-d-ribosyl
pyrophosphate to a
purine,
pyrimidine, or
pyridine acceptor, forming a 5′-nucleotide and
pyrophosphate, or d-ribose from d-ribosyl
phosphate to a
base, forming a
nucleoside, or similar
pentose transfers; important in
nucleotide biosynthesis.
Specific phosphoribosyltransferases are preceded by the name of the
acceptor base, e.g.,
uracil p. (
i.e.,
uracil +
PRPP ⇋ UMP + pyrophosphate).
* * *
* * *
phos·pho·ri·bo·syl·trans·fer·ase (fos″fo-ri″bo-səl-transґfər-ās) a term used in the recommended and trivial names of some pentosyltransferases [EC 2.4.2] to denote those that catalyze the transfer of ribose 5-phosphate, usually from phosphoribosylpyrophosphate, to a purine or pyrimidine to form a 5′ nucleotide and inorganic pyrophosphate. These enzymes are important in the biosynthesis of nucleotides.
Medical dictionary.
2011.
Look at other dictionaries:
Phosphoribosyltransferase — may refer to: * Adenine phosphoribosyltransferase * Hypoxanthine guanine phosphoribosyltransferase * Orotidine 5 phosphate decarboxylase * Uracil phosphoribosyltransferase … Wikipedia
phosphoribosyltransferase — noun Any transferase that involves phosphoribosyl pyrophosphate … Wiktionary
Adenine phosphoribosyltransferase — Adenine phosphoribosyltransferase, also known as APRT, is a human gene.cite web | title = Entrez Gene: APRT adenine phosphoribosyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=353| accessdate … Wikipedia
Nicotinamide phosphoribosyltransferase — PDB rendering based on 2g95 … Wikipedia
Hypoxanthine-guanine phosphoribosyltransferase — (HPRTcite web |url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene cmd=retrieve dopt=default list uids=3251 rn=1 |title=Entrez Gene: hypoxanthine phosphoribosyltransferase 1 (Lesch Nyhan syndrome)] ) is an enzyme in purine metabolism. PBB… … Wikipedia
Nicotinate-nucleotide—dimethylbenzimidazole phosphoribosyltransferase — Identifiers EC number 2.4.2.21 CAS number 37277 76 2 … Wikipedia
Adenine phosphoribosyltransferase deficiency — (also called 2,8 dihydroxyadenine urolithiasis) is an autosomal recessivecite journal |pmid=8976113 |year=1996 |month=Dec |author=Kamatani, N |title=Adenine phosphoribosyltransferase(APRT) deficiency |volume=54 |issue=12 |pages=3321–7 |issn=0047… … Wikipedia
Orotate phosphoribosyltransferase — S. cerevisiae orotate phosphoribosyl transferase bound to its substrates. From PDB file 2PSI.[ … Wikipedia
Anthranilate phosphoribosyltransferase — In enzymology, an anthranilate phosphoribosyltransferase (EC number|2.4.2.18) is an enzyme that catalyzes the chemical reaction:N (5 phospho D ribosyl) anthranilate + diphosphate ightleftharpoons anthranilate + 5 phospho alpha D ribose 1… … Wikipedia
ATP phosphoribosyltransferase — In enzymology, an ATP phosphoribosyltransferase (EC number|2.4.2.17) is an enzyme that catalyzes the chemical reaction:1 (5 phospho D ribosyl) ATP + diphosphate ightleftharpoons ATP + 5 phospho alpha D ribose 1 diphosphateThus, the two substrates … Wikipedia
