An inherited disorder in how the body absorbs and stores iron. The excess iron gives the skin a bronze color and damages the liver and other organs. Diabetes is also a part of the syndrome due to damage to the pancreas.
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A disorder of iron metabolism characterized by excessive absorption of ingested iron, saturation of iron-binding protein, and deposition of hemosiderin in tissue, particularly in the liver, pancreas, and skin; cirrhosis of the liver, diabetes (bronze diabetes), bronze pigmentation of the skin, and, eventually heart failure may occur; also can result from administration of large amounts of iron orally, by injection, or in forms of blood transfusion therapy. [hemo- + G. chroma, color, + -osis, condition]
- exogenous h. hemosiderosis due to repeated blood transfusions; it can progress to pigmentary cirrhosis.
- primary h. [MIM*235200] a specific inherited metabolic defect with increased absorption and accumulation of iron on a normal diet; autosomal recessive inheritance caused by a mutation in the h. gene (HFE) on 6p, less florid in females; juvenile h. may represent a homozygous state of the same gene.
- secondary h. increased intake and accumulation of iron secondary to known cause, such as oral iron therapy or multiple transfusions.

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he·mo·chro·ma·to·sis or chiefly Brit hae·mo·chro·ma·to·sis .hē-mə-.krō-mə-'tō-səs n, pl -to·ses -.sēz a hereditary disorder of metabolism that involves the deposition of iron-containing pigments in the tissues, is characterized esp. by joint or abdominal pain, weakness, and fatigue, may lead to bronzing of the skin, arthritis, diabetes, cirrhosis, or heart disease if untreated, and typically affects men more often than women compare HEMOSIDEROSIS
he·mo·chro·ma·tot·ic or chiefly Brit hae·mo·chro·ma·tot·ic -'tät-ik adj

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he·mo·chro·ma·to·sis (he″mo-kro″mə-toґsis) [hemo- + chromatosis] a syndrome of organ damage resulting from accumulation of iron in the tissues, causing damage and dysfunction of the liver, pancreas, heart, joints, and endocrine organs, and leading to organ failure. Classic clinical signs include bronze pigmentation of skin, arthropathy, diabetes mellitus, cirrhosis, hepatosplenomegaly, hypogonadism, and loss of body hair. Full development of the condition among women is restricted by menstruation and pregnancy. Cf. hemosiderosis and siderosis. hemochromatotic adj


Medical dictionary. 2011.

Look at other dictionaries:

  • hemochromatosis — [hē΄mə krō΄mə tō′sis, hem΄əkrō΄mə tō′sis] n. [ HEMO + CHROMAT(O) + OSIS] a disorder of iron metabolism, characterized by a bronze colored skin pigmentation, liver dysfunction, an excess of iron in body organs, and diabetes mellitus …   English World dictionary

  • hemochromatosis — hemochromatotic /hee moh kroh meuh tot ik, hem oh /, adj. /hee meuh kroh meuh toh sis, hem euh /, n. Pathol. a rare metabolic disorder characterized by a bronzed skin, cirrhosis, and severe diabetes, caused by the deposit in tissue, esp. of the… …   Universalium

  • hemochromatosis — noun pathology in which iron accumulates in the tissues; characterized by bronzed skin and enlarged liver and diabetes mellitus and abnormalities of the pancreas and the joints • Syn: ↑iron storage disease, ↑iron overload, ↑bronzed diabetes •… …   Useful english dictionary

  • hemochromatosis — A condition in which the body absorbs more iron from food than it needs. The extra iron is stored in and may damage the liver, heart, and pancreas. It may cause organ failure, cancer, heart problems, and liver disease. Hemochromatosis may also… …   English dictionary of cancer terms

  • hemochromatosis [hereditary] — hemochromatosis [hereditary]. См. гемохроматоз [наследственный]. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • hemochromatosis — noun Etymology: New Latin, from hem + chromat + osis Date: 1899 a hereditary disorder of metabolism involving the deposition of iron containing pigments in the tissues that is characterized especially by joint or abdominal pain, weakness, and… …   New Collegiate Dictionary

  • hemochromatosis — noun /ˌhiːməʊkɹəʊməˈtəʊsɪs/ a metabolic disorder causing iron deposits in the body, also called bronze diabetes …   Wiktionary

  • hemochromatosis — n. (Medicine) genetic disorder in which the body absorbs too much iron and stores it in the bodily organs (can cause organ damage, diabetes, and skin discoloration) …   English contemporary dictionary

  • hemochromatosis — he·mo·chromatosis …   English syllables

  • hemochromatosis — he•mo•chro•ma•to•sis [[t]ˌhi məˌkroʊ məˈtoʊ sɪs[/t]] n. pat a disorder of iron metabolism manifested by bronzed skin due to excessive iron absorption, leading to joint pain, diabetes, and liver damage if iron concentration is not reduced •… …   From formal English to slang

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