A protein found in the cytoplasmic granules of both T cytotoxic lymphocytes and natural killer cells. This protein is implicated in target cell lysis by the above cells. [L. per-foro, to bore, pierce, + -in]

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per·for·in (purґfə-rin) a protein expressed by cytotoxic lymphocytes and forming a transmembrane pore at the site of target cell lysis.

Medical dictionary. 2011.

Look at other dictionaries:

  • Perforin — 1 (pore forming protein), also known as PRF1, is a human gene.cite web | title = Entrez Gene: PRF1 perforin 1 (pore forming protein)| url = Cmd=ShowDetailView TermToSearch=5551| accessdate = ]… …   Wikipedia

  • Perforin — 1 Vorhandene Strukturdaten …   Deutsch Wikipedia

  • perforin — per·fo·rin (pûrʹfər ĭn) n. A protein in killer cells and natural killer cells that causes lysis of target cells on contact.   [perforate + in.] * * * …   Universalium

  • perforin — noun A cytolytic protein found in natural killer cells …   Wiktionary

  • perforin — [ pə:fərɪn] noun Biochemistry a protein, released by killer cells of the immune system, which destroys targeted cells by creating lesions like pores in their membranes. Origin 1980s: from perforate + in1 …   English new terms dictionary

  • perforin — n. a protein produced by cytotoxic T cells and natural killer cells that are in contact with virus infected target cells. It creates pores in the target cell membrane, which facilitates the delivery of granzymes to the cell to induce cell death… …   The new mediacal dictionary

  • perforin — …   Useful english dictionary

  • perforin pathway — The cytotoxic pathway that uses perforin protein, which polymerizes to form membrane pores that help destroy cells during cell mediated cytotoxicity. Perforin is produced by cytotoxic T cells and NK cells and stored in granules that are released… …   Dictionary of microbiology

  • MACPF — Pfam box Symbol = MACPF Name = MAC/Perforin domain width = caption = Pfam= PF01823 InterPro= IPR001862 SMART= MACPF PROSITE = PDOC00251 SCOP = TCDB = 1.C.39 OPM family= OPM protein= PDB=The MACPF protein superfamily is named after a domain that… …   Wikipedia

  • Granzyme — Granzymes are serine proteases that are released by cytoplasmic granules within cytotoxic T cells and natural killer cells. Their purpose is to induce apoptosis within virus infected cells, thus destroying them.cite journal |author=Bots M, Medema …   Wikipedia

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