nuclease

nuclease
General term for enzymes that catalyze the hydrolysis of nucleic acid into nucleotides or oligonucleotides by cleaving phosphodiester linkages. For nucleases not listed below, see the specific term. Cf.:exonuclease, endonuclease.
- azotobacter n. endonuclease (Serratia marcescens).
- micrococcal n. SYN: micrococcal endonuclease.
- mung bean n. endonuclease S1 (Aspergillus).

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nu·cle·ase 'n(y)ü-klē-.ās, -.āz n any of various enzymes that promote hydrolysis of nucleic acids

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n.
an enzyme that catalyses the breakdown of nucleic acids by cleaving the bonds between adjacent nucleotides. Examples are ribonuclease, which acts on RNA, and deoxyribonuclease, which acts on DNA.

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nu·cle·ase (nooґkle-ās) a general term for enzymes of the hydrolase class that catalyze the cleavage of phosphodiester linkages in nucleic acids to form nucleotides or oligonucleotides [EC 3.1.11–31]. The nucleases are classified in subgroups on the basis of their substrate specificity; they may be endonucleases or exonucleases, each of which may be specific for the ribonucleic acids (ribonucleases) or deoxyribonucleic acids (deoxyribonucleases).

Medical dictionary. 2011.

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  • nucléase — [ nykleaz ] n. f. • 1907; de nuclé(o) et ase ♦ Biochim. Enzyme qui catalyse l hydrolyse des acides nucléiques. ⇒ désoxyribonucléase, ribonucléase. ● nucléase nom féminin Enzyme qui catalyse la scission des acides nucléiques. (Il en existe deux… …   Encyclopédie Universelle

  • Nuclease — Nucléase Les nucléases sont des enzymes qui coupent les liaisons phosphodiesters des brins d acide nucléique entre deux nucléotides[1]. Sources ↑ Conseil consultatif canadien de la biotechnologie Glossaire Liens internes …   Wikipédia en Français

  • nuclease — nuclease. См. нуклеаза. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • nuclease — [no͞o′klē ās΄, nyo͞o′klē ās΄] n. [ NUCLE(O) + ASE] any of various enzymes that speed up the hydrolysis of nucleic acids …   English World dictionary

  • Nuclease — A nuclease is an enzyme capable of cleaving the phosphodiester bonds between the nucleotide subunits of nucleic acids. Older publications may use terms such as polynucleotidase or nucleodepolymerase .[1] Nucleases are usually further divided into …   Wikipedia

  • Nucléase — Les nucléases sont des enzymes qui coupent les liaisons phosphodiesters des brins d acide nucléique entre deux nucléotides[1]. Notes et références ↑ Conseil consultatif canadien de la bi …   Wikipédia en Français

  • nuclease — nukleazė statusas T sritis chemija apibrėžtis Fermentas, katalizuojantis nukleorūgščių fosfodiesterinių ryšių hidrolizę. atitikmenys: angl. nuclease rus. нуклеаза …   Chemijos terminų aiškinamasis žodynas

  • nuclease — A class of largely bacterial enzymes that degrade DNA or RNA molecules by catalysing the cleavage of the phosphodiester bonds that link adjacent nucleotides. For deoxyribonuclease (DNAse) the substrate is DNA, for ribonuclease (RNAse) the… …   Glossary of Biotechnology

  • Nuclease protection assay — is a laboratory technique used in biochemistry and genetics to identify individual RNA molecules in a heterogeneous RNA sample extracted from cells. The technique can identify one or more RNA molecules of known sequence even at low total… …   Wikipedia

  • Nucléase à doigt de zinc — Les nucléases à doigts de zinc sont des enzymes de restriction artificielles créées par la fusion d un domaine de liaison à l ADN, de type « doigt de zinc », et d un domaine catalytique de coupure de l ADN (nucléase). Ingénierie par… …   Wikipédia en Français

  • nuclease — noun Date: 1902 any of various enzymes that promote hydrolysis of nucleic acids …   New Collegiate Dictionary

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