neostigmine

neostigmine
A synthetic compound, similar in action to physostigmine (eserine); a reversible cholinesterase inhibitor, used as the bromide or methylsulfate salts in the treatment of myasthenia gravis, postoperative distention, urinary retention, and antagonist of stabilizing neuromuscular blocking drugs.

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neo·stig·mine .nē-ə-'stig-.mēn n a cholinergic drug used in the form of its bromide C12H19BrN2O2 or a methyl sulfate derivative C13H22N2O6S esp. in the diagnosis and treatment of myasthenia gravis and in the treatment of urinary bladder or bowel atony see PROSTIGMIN

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n.
an anticholinesterase drug used mainly to diagnose and treat myasthenia gravis and as an antidote to some muscle relaxant drugs. It is administered by mouth or injection; side-effects include digestive upsets and increased saliva flow.

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neo·stig·mine (ne″o-stigґmēn) a cholinesterase inhibitor and prokinetic agent, which acts by inhibiting destruction of acetylcholine and so facilitating transmission of impulses across the neuromuscular junction. Effects include miosis, bradycardia, increased intestinal and skeletal muscle tone, increased salivary and sweat gland secretion, and constriction of bronchi and ureters. It also has direct effects on skeletal muscle fibers.

Medical dictionary. 2011.

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  • neostigmine bromide — [USP] the bromide salt of neostigmine, used as a cholinergic in the symptomatic control of myasthenia gravis, and to produce miosis in certain forms of glaucoma in patients who have developed tolerance to other miotics; administered orally and… …   Medical dictionary

  • neostigmine methylsulfate — [USP] the methylsulfate salt of neostigmine, used as a cholinergic in the symptomatic treatment of myasthenia gravis, as a diagnostic test for myasthenia gravis, in the prevention and treatment of postoperative stasis and atony of the… …   Medical dictionary

  • neostigmine test — (for myasthenia gravis) used in children, and in adults suspected of having myasthenia gravis but with a negative Tensilon test; neostigmine methylsulfate mixed with atropine sulfate is injected intramuscularly. This will relieve symptoms of… …   Medical dictionary

  • neostigmine — noun Etymology: ne + stigmine (as in physostigmine) Date: 1941 a cholinergic drug used in the form of its bromide C12H19BrN2O2 or a methyl sulfate derivative C13H22N2O6S especially in the diagnosis and treatment of myasthenia gravis and in the… …   New Collegiate Dictionary

  • neostigmine — /nee oh stig meen, min/, n. Pharm. a synthetic anticholinesterase, C12H19N2O2, used in the treatment of myasthenia gravis, glaucoma, and postoperative urinary bladder distention. [1940 45; NEO + stigmine (after PROSTIGMIN; see INE2)] * * * …   Universalium

  • neostigmine — noun A parasympathomimetic, a reversible cholinesterase inhibitor …   Wiktionary

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