- 1. Physiologic or normal death of cells or tissues as a result of changes associated with development, aging, or use. 2. Necrosis of a small area of tissue. [necro- + G. bios, life]- n. lipoidica, n. lipoidica diabeticorum a condition, in many cases associated with diabetes, in which one or more yellow, atrophic, shiny lesions develop on the legs (typically pretibial); characterized histologically by indistinct areas of necrosis in the cutis.
* * *nec·ro·bi·o·sis -bī-'ō-səs n, pl -o·ses -.sēz death of a cell or group of cells within a tissue whether normal (as in various epithelial tissues) or part of a pathologic process compare NECROSIS
* * *n.a gradual process by which cells lose their function and die. Necrobiosis lipoidica is a disease in which degeneration of collagen produces sharply demarcated yellowish-brown plaques, especially on the shins of women. It is often, but not exclusively, associated with diabetes mellitus.
* * *nec·ro·bi·o·sis (nek″ro-bi-oґsis) [necro- + biosis] swelling, basophilia, and distortion of collagen bundles in the dermis, sometimes with obliteration of normal structure, but without actual necrosis, such as in granuloma annulare and necrobiosis lipoidica. Cf. gangrene and necrosis. necrobiotic adj
Medical dictionary. 2011.