mitomycin

mitomycin
Antibiotic produced by Streptomyces caespitosus, variants of which are designated m. A, m. B, etc.; m. C is an antineoplastic agent and a bacteriocide; inhibits DNA synthesis.

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mi·to·my·cin .mīt-ə-'mīs-ən n
1) a complex of antibiotic substances which is produced by a Japanese bacterium of the genus Streptomyces (S. caespitosus)
2) a component C15H18N4O5 of mitomycin that inhibits DNA synthesis and is used as an antineoplastic in the palliative treatment of some carcinomas called also mitomycin C

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an anthracycline antibiotic that inhibits the growth of cancer cells. It causes severe marrow suppression but is of use in the treatment of stomach and breast cancers. Trade name: Mitomycin C Kyowa.

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mi·to·my·cin (mi″to-miґsin) any of a group of antitumor antibiotics (e.g., mitomycin A, B, C) produced by Streptomyces caespitosus. [USP] mitomycin C, which acts as a bifunctional or trifunctional alkylating agent causing cross-linking of DNA and inhibition of DNA synthesis and is relatively phase-specific for the late G1 and early S phases of the cell cycle. It has activity against many types of carcinoma as well as chronic myelogenous leukemia, but because of its severe toxicity and myelosuppression it is usually used only for palliation in patients who have not responded to other treatment. Administered intravenously.

Medical dictionary. 2011.

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Look at other dictionaries:

  • Mitomycin — Preferred IUPAC name [6 Amino 8a methoxy 5 methyl 4,7 dioxo 1,1a,2,4,7,8,8a,8b octahydroazireno[2 ,3 :3,4]pyrrolo[1,2 a]indol 8 yl]me …   Wikipedia

  • Mitomycin — Strukturformel Allgemeines Freiname Mitomycin Andere Namen …   Deutsch Wikipedia

  • mitomycin C — Aziridine antibiotic isolated from Streptomyces caespitosus. Inhibits DNA synthesis by cross linking the strands and is used as an anti neoplastic agent. Most active in late G1 and early S phase. Mitomycin treated cells are sometimes used as… …   Dictionary of molecular biology

  • mitomycin — an anthracycline antibiotic that inhibits the growth of cancer cells. Administered by injection or bladder instillation, it causes severe marrow suppression but is of use in the treatment of stomach, breast, and bladder cancers. Trade names:… …   The new mediacal dictionary

  • mitomycin — noun Etymology: International Scientific Vocabulary mito (probably from New Latin mitosis) + mycin Date: 1956 a complex of antibiotic substances that is produced by a Japanese streptomyces (Streptomyces caespitosus); especially one form… …   New Collegiate Dictionary

  • mitomycin — mi·to·my·cin (mī tə mīʹsĭn) n. Any of a group of antibiotics produced by the soil actinomycete Streptomyces caespitosus that inhibit DNA synthesis and are used against bacteria and cancerous tumor cells.   [Probably mitosis + mycin.] * * * …   Universalium

  • mitomycin — noun Any of a family of aziridine containing natural products isolated from the filamentous bacterium Streptomyces lavendulae, one of which is used as a chemotherapeutic agent …   Wiktionary

  • Mitomycin — Mi|to|my|cin [... tsi:n] u. Mi|to|my|zin das; s, e Kurzw. aus ↑Mitoseu. ↑Streptomycin> (vor allem in der Krebstherapie angewendetes) ↑zytostatischwirksames ↑Antibiotikum …   Das große Fremdwörterbuch

  • mitomycin — mi·to·my·cin …   English syllables

  • mitomycin — An anticancer drug that belongs to the family of drugs called antitumor antibiotics …   English dictionary of cancer terms

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