metyrapone

metyrapone
An inhibitor of adrenocortical steroid C-11 β-hydroxylation, administered orally or intravenously to determine the ability of the pituitary gland to increase its secretion of corticotropin; because 11-deoxycorticosteroids, as a consequence of m. administration, only weakly inhibit pituitary corticotropin secretion, the normal pituitary gland will appreciably increase its output of this hormone. SYN: mepyrapone.

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me·tyr·a·pone mə-'tir-ə-.pōnalso -'tīr- n a metabolic hormone C14H14N2O that inhibits biosynthesis of cortisol and corticosterone and is used to test for normal functioning of the pituitary gland see METOPIRONE

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n.
a drug that interferes with the production of the hormones cortisol and aldosterone and is used in the treatment of Cushing's syndrome. It is administered by mouth. Side-effects may include nausea, vomiting, low blood pressure, and allergic reactions. Trade name: Metopirone.

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me·tyr·a·pone (mə-tērґə-pōn) [USP] an inhibitor of the enzyme steroid 11β-hydroxylase; used in a test of hypothalamic-pituitary function. See metyrapone test, under tests.

Medical dictionary. 2011.

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Look at other dictionaries:

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  • metyrapone test — (for Cushing syndrome) plasma 11 deoxycortisol or urinary 17 hydroxycorticosteroids are measured after the administration of metyrapone; levels are increased in patients with Cushing disease but not in patients with ectopic ACTH syndrome …   Medical dictionary

  • metyrapone — noun A drug used in the control of hypercortisolism …   Wiktionary

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  • metyrapone — məˈtirəˌpōn noun ( s) Etymology: methyl + rapone (perhaps alteration of propanone) : a metabolic hormone C14H14N2O that inhibits biosynthesis of cortisol and corticosterone and is used to test for normal functioning of the pituitary gland …   Useful english dictionary

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