methotrexate

methotrexate

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meth·o·trex·ate .meth-ə-'trek-.sāt n a toxic drug C20H22N8O5 that is an analog of folic acid and is used to treat certain cancers, severe psoriasis, and rheumatoid arthritis called also amethopterin

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n.
a drug that interferes with cell growth and is used to treat various types of cancer, including leukaemia and breast cancer (see antimetabolite). It is administered by mouth or injection; common side-effects include mouth sores, digestive upsets, skin rashes, and hair loss. Trade name: Maxtrex.

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meth·o·trex·ate (MTX) (meth″o-trekґsāt) [USP] a folic acid antagonist that acts by inhibiting synthesis of DNA, RNA, thymidylate, and protein; used as an antineoplastic in treatment of a wide variety of malignancies, including acute lymphocytic, meningeal, and acute myelocytic leukemia; gestational choriocarcinoma; chorioadenoma destruens; hydatidiform mole; carcinoma of the breast, lung, and head and neck; non-Hodgkin lymphomas; mycosis fungoides; and osteosarcoma; administered orally. It is also used as an antipsoriatic and antiarthritic in the treatment of severe, recalcitrant, disabling psoriasis and severe rheumatoid and psoriatic arthritis.

Medical dictionary. 2011.

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  • Methotrexate — Méthotrexate Méthotrexate Général Nom IUPAC acide (2S) 2 [(4 {[(2,4 diamino 7,8 dihydroptéridin 6 yl)méthyl](méthyl)amino}phényl)formamido] pentanedioïque …   Wikipédia en Français

  • Méthotrexate — Général Nom IUPAC acide (2S) 2 [(4 {[(2,4 diamino 7,8 dihydroptéridin 6 yl)méthyl](méthyl)amino}phényl)formamido] pentanedioïque …   Wikipédia en Français

  • methotrexate — methotrexate. См. метотрексат. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • méthotréxate — ● méthotréxate nom masculin Médicament antimitotique, dérivé antagoniste de l acide folique, utilisé dans le traitement de diverses tumeurs et de certaines leucémies …   Encyclopédie Universelle

  • methotrexate — [meth΄ō treks′āt΄] n. [ METH(YL) + trex (< ?) + ATE2] an orange brown, crystalline powder, C20H22N8O5, that is a folic acid antagonist: used in medicine, esp. in treating leukemia, various tumors, psoriasis, and rheumatoid arthritis …   English World dictionary

  • Methotrexate — Amethopterin redirects here. Not to be confused with aminopterin. Methotrexate Systematic ( …   Wikipedia

  • Methotrexate — Strukturformel Allgemeines Freiname Methotrexat Andere Namen …   Deutsch Wikipedia

  • methotrexate — /meth oh trek sayt/, n. Pharm. a toxic folic acid analogue, C20H22N8O5, that inhibits cellular reproduction, used primarily in the treatment of psoriasis and certain cancers and as an immunosuppressive agent. [1950 55; METHO(XY) + trexate, of… …   Universalium

  • methotrexate — n. a drug that interferes with cell growth and is used to treat many types of cancer, including leukaemia in children and various solid tumours (see antimetabolite, dihydrofolate reductase inhibitor). It also affects the immune response and may… …   The new mediacal dictionary

  • methotrexate — noun toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis • Syn: ↑methotrexate sodium, ↑amethopterin • Hypernyms: ↑antimetabolite,… …   Useful english dictionary

  • Methotrexate-induced papular eruption — appears in patients being treated with methotrexate, such as those with rheumatic disease, presenting with erythematous indurated papules, usually located on the proximal extremities.[1] It has been suggested that it may represent a Cutaneous… …   Wikipedia

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