megaloblast

megaloblast
A large, nucleated, embryonic type of cell that is a precursor of erythrocytes in an abnormal erythropoietic process observed in pernicious anemia; a megaloblasts four stages of development are as follows: 1) promegaloblast, 2) basophilic m., 3) polychromatic m., 4) orthochromatic m.. SEE ALSO: erythroblast. [megalo- + G. blastos, + germ, sprout]

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meg·a·lo·blast 'meg-ə-lō-.blast n a large erythroblast that appears in the blood esp. in pernicious anemia
meg·a·lo·blas·tic .meg-ə-lō-'blas-tik adj

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n.
an abnormal form of any of the cells that are precursors of red blood cells (see erythroblast). Megaloblasts are unusually large and their nuclei fail to mature in the normal way; they are seen in the bone marrow in certain anaemias (megaloblastic anaemias) due to deficiency of vitamin B12 or folic acid.
• megaloblastic adj.

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meg·a·lo·blast (megґə-lo-blast″) [megalo- + -blast] a large, nucleated, immature progenitor of an abnormal red blood cell series seen in some types of anemia; it follows the promegaloblast in development and retains some of its features. Megaloblasts correspond to normoblasts (see erythroblast) of the normal red cell maturation series and are correspondingly classified as basophilic, polychromatophilic, and orthochromatic. See also megaloblastic anemia, under anemia.

Medical dictionary. 2011.

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  • megaloblast — MEGALOBLÁST, megaloblaste, s.n. (biol.) Globulă roşie cu nucleul anormal mărit, caracteristică în anemia pernicioasă; (rar) macroblast. – Din fr. mégaloblaste, engl. megaloblast. Trimis de claudia, 13.09.2007. Sursa: DEX 98  megaloblást s. n.,… …   Dicționar Român

  • Megaloblast — A megaloblast is an unusually large erythroblast that can be associated with pernicious anemia (Vitamin B12 deficiency) and folic acid deficiency (collectively called megaloblastic anemia). It is differentiated from a normoblast, which is a… …   Wikipedia

  • megaloblast — noun Date: 1890 a large erythroblast that appears in the blood especially in pernicious anemia • megaloblastic adjective …   New Collegiate Dictionary

  • megaloblast — megaloblastic, adj. /meg euh leuh blast /, n. Pathol. an abnormally large, immature, and dysfunctional red blood cell found in the blood of persons with pernicious anemia or certain other disorders. [1895 1900; MEGALO + BLAST] * * * …   Universalium

  • megaloblast — noun An abnormally large red blood cell associated with pernicious anemia and with folic acid deficiency …   Wiktionary

  • Megaloblast — Als Megaloblasten werden ungewöhnlich große, kern und hämoglobinhaltige Vorläuferzellen der Erythrozyten im Knochenmark bezeichnet. Sie entwickeln sich aus dem noch hämoglobinfreien Promegaloblasten. Die reifen, vergrößerten Erythrozyten werden… …   Deutsch Wikipedia

  • Megaloblast — Me|ga|lo|blạst, der; en, en <meist Pl.> [zu griech. mégas (megal ) = groß u. blastós = Keim] (Med.): abnorm große, kernhaltige Vorstufe der roten Blutkörperchen …   Universal-Lexikon

  • megaloblast — me|ga|lo|blast Mot Agut Nom masculí …   Diccionari Català-Català

  • Megaloblast — Me|ga|lo|blạst 〈m.; Gen.: en, Pl.: en; meist Pl.; Med.〉 abnorm große Vorstufe der roten Blutkörperchen [Etym.: <Megalo… + …blast] …   Lexikalische Deutsches Wörterbuch

  • Megaloblast — Megalo|blạst [↑mega... u. ↑...blast] m; en, en (meist Mehrz.): abnorm große, kernhaltige Vorstufe der roten Blutkörperchen …   Das Wörterbuch medizinischer Fachausdrücke

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