malate

A salt or ester of malic acid.

- m. dehydrogenase an enzyme that catalyzes, through NAD⁺ or NADP⁺, the dehydrogenation of m. to oxaloacetate or its decarboxylation to pyruvate and CO₂. At least six m. dehydrogenases are known, distinguished by their products, use of NAD⁺ or NADP⁺, and specificity of substrate (one acts on d-m., the rest act on l-m.); one is an enzyme in the tricarboxylic acid cycle. SYN: malic acid dehydrogenase, malic dehydrogenase, malic enzyme, pyruvic-malic carboxylase.

- m. synthase an enzyme catalyzing the reversible condensation of acetyl-CoA with glyoxylate and water to form l-m. and coenzyme A; an enzyme in the glyoxylate cycle. SYN: glyoxylate transacetylase, m.-condensing enzyme.

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ma·late 'mal-.āt, 'mā-.lāt n a salt or ester of malic acid

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ma·late (maґlāt) (malґāt) an ionic form of malic acid.