lovastatin

lovastatin
A cholesterol-lowering agent, isolated from a strain of Aspergillus terreus, that reduces both normal and elevated serum cholesterol. SYN: mevinolin.

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lov·a·stat·in 'lō-və-.stat-ən, 'ləv-ə- n a drug C24H36O8 that decreases the level of cholesterol in the bloodstream by inhibiting the liver enzyme that controls cholesterol synthesis and is used in the treatment of hypercholesterolemia see MEVACOR

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lo·va·stat·in (loґvə-stat″in) [USP] an inhibitor of HMG-CoA reductase, which can lower plasma levels of cholesterol and raise the plasma level of high-density lipoprotein C (HDL-C); used in the treatment of hypercholesterolemia and other forms of dyslipidemia and to reduce the risk of morbidity and mortality associated with atherosclerosis and coronary heart disease; administered orally.

Medical dictionary. 2011.

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Look at other dictionaries:

  • Lovastatin — Systematic (IUPAC) name (1S,3R,7S,8S …   Wikipedia

  • lovastatin — [lō′və stat΄in, lō΄və stat′in] n. 1. a white, crystalline powder, C24H36O5 2. a drug made of this powder, used to reduce the levels of LDL and cholesterol in the blood …   English World dictionary

  • Lovastatin — Strukturformel Allgemeines Freiname Lovastatin Ander …   Deutsch Wikipedia

  • lovastatin — noun Etymology: probably from International Scientific Vocabulary mevalonic acid, a carboxylic acid, C6H12O4 (from methyl + valeric + onic as in gluconic acid) + mevastatin, a fungal metabolite structurally similar to lovastatin, from mevalonic + …   New Collegiate Dictionary

  • Lovastatin — ЛОВАСТАТИН ( Lovastatin )*. Ловастатин является гипохолестеринемическим веществом, выделенным из штамма Аspergillus terreus. [1S (1 a (R*),З a ,7 b ,8 b (2S*,4S*),8 ab ] 1,2,3,7,8,8 a Гексагидро 3,7 диметил 8[2 (тетрагидро) 4 гидрокси 6 оксо 2Н… …   Словарь медицинских препаратов

  • Lovastatin nonaketide synthase — In enzymology, a lovastatin nonaketide synthase (EC number|2.3.1.161) is an enzyme that catalyzes the chemical reaction:acetyl CoA + 8 malonyl CoA + 11 NADPH + 10 H+ + S adenosyl L methionine ightleftharpoons dihydromonacolin L + 9 CoA + 8 CO2 +… …   Wikipedia

  • lovastatin — (= mevinolin; 6a methylcompactin) Fungal metabolite that inhibits hydroxymethylglutaryl CoA reductase (HMGCoA reductase) and is used as an anti hypercholesterolemic drug …   Dictionary of molecular biology

  • lovastatin — /loh veuh stat n/, n. a drug that reduces the levels of fats in the blood by altering the enzyme activity in the liver that produces lipids. [1985 90; of undetermined orig.] * * * …   Universalium

  • lovastatin — noun A statin that inhibits the synthesis of cholesterol …   Wiktionary

  • lovastatin — lov·a·stat·in …   English syllables

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