kininogen

kininogen
- high molecular weight k. a plasma protein of 110,000 molecular weight that normally exists in plasma in a 1:1 complex with prekallikrein. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to kallikrein. SYN: Fitzgerald factor, Flaujeac factor, Williams factor.
- low molecular weight k. a protein of 50,000 molecular weight that occurs in various normal tissues and which, upon cleavage by kallikrein or other kininogens, forms kallidin. Kallidin, in turn, is converted into bradykinin.

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ki·nin·o·gen kī-'nin-ə-jən n an inactive precursor of a kinin
ki·nin·o·gen·ic (.)kī-.nin-ə-'jen-ik adj

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ki·nin·o·gen (ki-ninґo-jen″) either of two plasma α2-globulins that are kinin precursors, called high-molecular-weight k. and low-molecular-weight k.

Medical dictionary. 2011.

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  • Kininogen — Kinine sind zu den Gewebshormonen zählende biologisch aktive Oligopeptide, sie werden von Kallikrein aus Kininogenen (inaktive Vorstufe von Kininen) freigesetzt. Das Kinin Kallikrein System oder einfach Kininsystem ist ein schlecht abgrenzbares… …   Deutsch Wikipedia

  • Kininogen — Kininogens are proteins that are defined by their role as precursors for kinin, but that also can have additional roles. The two main types are: * High molecular weight kininogen, which is produced by the liver together with prekallikrein. It… …   Wikipedia

  • kininogen — Inactive precursor in plasma from which kinin is produced by proteolytic cleavage …   Dictionary of molecular biology

  • kininogen — noun Any of a set of proteins defined by their primary role as precursors for kinin …   Wiktionary

  • kininogen — ki|ni|no|gen [↑ gen] ↑ Kinin …   Universal-Lexikon

  • kininogen — ki·nin·o·gen …   English syllables

  • kininogen — …   Useful english dictionary

  • High-molecular-weight kininogen — (HMWK), also known as the Williams Fitzgerald Flaujeac factor or the Fitzgerald factor or the HMWK kallikrein factor, is a protein from the blood coagulation system as well as the kinin kallikrein system. It is a protein that adsorbs to the… …   Wikipedia

  • Low-molecular-weight kininogen — is a form of kininogen, which has been identified in mice, [cite journal |author=Shesely E, Hu C, Alhenc Gelas F, Meneton P, Carretero O |title=A second expressed kininogen gene in mice |journal=Physiol Genomics |volume=26 |issue=2 |pages=152–7… …   Wikipedia

  • high-molecular-weight kininogen — (HMWK) a kininogen of molecular weight 100,000–250,000 that is split by plasma kallikrein to produce bradykinin. Called also Fitzgerald factor …   Medical dictionary

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