isoniazid

Isonicotinic acid hydrazide; first-line and probably most commonly used antituberculosis drug. Organisms rapidly develop resistance against this drug if it is used alone in the treatment of active disease. Hepatic toxicity is the major side effect.

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iso·ni·a·zid .ī-sə-'nī-ə-zəd n a crystalline compound C₆H₇N₃O used in treating tuberculosis called also isonicotinic acid hydrazide

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(isonicotinic acid hydrazide, INH)

n.

a drug used in the treatment of tuberculosis, usually taken by mouth. Because tuberculosis bacteria soon become resistant to isoniazid, it is usually given in conjunction with other antibiotics. Occasional side-effects include digestive disturbances and dry mouth; high doses or prolonged treatment may cause inflammation of the nerves, which can be countered by including pyridoxine (vitamin B₆) in the preparation.

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iso·ni·a·zid (INH) (i″so-niґə-zid) [USP] an antibacterial, used as a tuberculostatic, administered orally and intramuscularly.