Decreased quantity of the gamma fraction of serum globulin; sometimes used loosely to denote decreased quantity of immunoglobulins in general; associated with increased susceptibility to pyogenic infections. SYN: hypogammaglobinemia.
- acquired h. SYN: common variable immunodeficiency.
- primary h. h. due to a primary immunodeficiency of immunoglobulin-forming cells (B-lymphocytes).
- secondary h. SYN: secondary immunodeficiency.
- transient h. of infancy a type of primary immunodeficiency that occurs in infants of both sexes, usually before the sixth month of life, probably resulting from immaturity of lymphoid tissue. SYN: transient agammaglobulinemia.
- X-linked h., X-linked infantile h. a congenital, primary immunodeficiency characterized by decreased numbers (or absence) of circulating B lymphocytes with corresponding decrease in immunoglobulins of the five classes; associated with marked susceptibility to infection by pyogenic bacteria (notably, pneumococci and Haemophilus influenzae) beginning after loss of maternal antibodies; X-linked recessive inheritance caused by mutation in the Bruton tyrosine kinase gene (BTK) on Xq.
- X-linked h. with growth hormone deficiency h. combined with a reduced number of B cells; characterized by short stature, delayed puberty, and recurrent infections.

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hy·po·gam·ma·glob·u·lin·emia or chiefly Brit hy·po·gam·ma·glob·u·lin·ae·mia -.gam-ə-.gläb-yə-lə-'nē-mē-ə n a deficiency of gamma globulins and esp. antibodies in the blood also a state of immunological deficiency characterized by this
hy·po·gam·ma·glob·u·lin·emic or chiefly Brit hy·po·gam·ma·glob·u·lin·ae·mic -'nē-mik adj

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hy·po·gam·ma·glob·u·lin·emia (hi″po-gam″ə-glob″u-lĭ-neґme-ə) abnormally low levels of all classes of immunoglobulins in the blood; see also agammaglobulinemia, dysglobulinemia, and immunodeficiency.

Medical dictionary. 2011.

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  • Transient hypogammaglobulinemia of infancy — Infobox Disease Name = PAGENAME Caption = DiseasesDB = ICD10 = ICD10|D|80|7|d|80 ICD9 = ICD9|279.09 ICDO = OMIM = MedlinePlus = eMedicineSubj = ped eMedicineTopic = 2280 MeshID = Transient hypogammaglobulinemia of infancy is a form of… …   Wikipedia

  • physiologic hypogammaglobulinemia — a normal period of hypogammaglobulinemia seen in all infants at about 5–6 months of age as the level of transplacentally acquired maternal immunoglobulins declines before endogenous immunoglobulin synthesis rises to normal levels …   Medical dictionary

  • transient hypogammaglobulinemia of infancy — prolongation of the normal physiologic hypogammaglobulinemia of infancy caused by delayed development of endogenous immunoglobulin production and associated with increased susceptibility to infections …   Medical dictionary

  • X-linked hypogammaglobulinemia — X linked infantile hypogammaglobulinemia see under agammaglobulinemia …   Medical dictionary

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