- Any of a group of conditions in which the cellular components of the blood or platelets are removed at an abnormally high rate by the spleen, resulting in low circulating levels.
* * *hy·per·sple·nism -'splē-.niz-əm, -'splen-.iz- n a condition marked by excessive destruction of one or more kinds of blood cells in the spleenhy·per·splen·ic -'splen-ik adj
* * *n.a decrease in the numbers of red cells, white cells, and platelets in the blood resulting from destruction or pooling of these cells by an enlarged spleen. Hypersplenism may occur in any condition in which there is enlargement of the spleen (see splenomegaly).
* * *hy·per·splen·ism (hi″pər-splenґiz-əm) a condition characterized by exaggeration of the suggested inhibitory or destructive functions of the spleen, resulting in deficiency of the peripheral blood elements, singly or in combination, hypercellularity of the bone marrow, and usually, but not always, splenomegaly.
Medical dictionary. 2011.