- hydroxyurea
- An oral antineoplastic agent that inhibits DNA synthesis; used in the treatment of a variety of malignancies including melanoma, chronic myelocytic leukemia, and carcinoma of the ovary. SYN: hydroxycarbamide.
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hy·droxy·urea -yu̇-'rē-ə n an antineoplastic drug CH4N2O2 used esp. to treat melanoma, chronic myelogenous leukemia, and malignant tumors (as of the ovary or neck)* * *
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hy·droxy·urea (hi-drok″se-u-reґə) [USP] an inhibitor of the enzyme ribonucleoside diphosphate reductase, which catalyzes the conversion of ribonucleotides to deoxyribonucleotides, an essential step in DNA synthesis. It is used as an antineoplastic agent primarily for treatment of busulfan-resistant chronic granulocytic leukemia, and also for the treatment of carcinoma of the head and neck, ovary, and cervix, malignant melanoma, and polycythemia vera; administered orally. It is also used orally in sickle cell disease to reduce the frequency of painful crises and to reduce the need for blood transfusions.
Medical dictionary. 2011.