Part of a chromosome in duplicate, a particular kind of mutation (change) involving the production of one or more copies of any piece of DNA, including a gene or even an entire chromosome. Duplications typically arise from an event termed unequal crossing-over (a kind of recombination) that occurs between misaligned homologous chromosomes during meiosis (germ cell formation). The chance of this event happening is a function of the degree of sharing of repetitive elements between two chromosomes. The recombination products of such an event are a duplication at the site of the exchange and a reciprocal deletion. A remarkable class of duplications in which the duplicated region has popped up far away from home base has also been discovered. Duplications have been important in the evolution of the human genome (and the evolution of the genomes of many other organisms). A duplication is the opposite of a deletion.
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1. A doubling. SEE ALSO: reduplication. 2. Inclusion of two copies of the same genetic material in a genome; an important step in diversification of genomes, as in the evolution of the (nonallelic) hemoglobin chains from a common ancestor. SYN: gene d.. [L. duplicatio, a doubling, fr. duplico, to double]
- d. of chromosomes a chromosome aberration resulting from unequal crossing over or exchange of segments between two homologous chromosomes; one chromosome of the pair loses a small segment, while the other gains this segment; the chromosome gaining the segment has undergone d. while its homologue has undergone deletion. See hemoglobin Lepore.
- gene d. SYN: d. (2).

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du·pli·ca·tion .d(y)ü-pli-'kā-shən n
1) the act or process of duplicating: the quality or state of being duplicated
2) a part of a chromosome in which the genetic material is repeated also the process of forming a duplication

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du·pli·ca·tion (doo″plĭ-kaґshən) [L. duplicatio doubling] 1. the act or process of doubling, or the state of being doubled. 2. in genetics, the presence in the genome of additional genetic material (a chromosome or segment of one, a gene or part of one). See also repeat. 3. a doubling of parts, which may be connected at some point, the extra part may be a mirror image of the other. See also conjoined twins, under twin. Called also duplicitas and reduplication.

Medical dictionary. 2011.

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  • duplication — [ dyplikasjɔ̃ ] n. f. • XIIIe; lat. duplicatio → double 1 ♦ Vx ou didact. Opération par laquelle on double (une quantité, un volume). Duplication du cube : construction d un cube double d un autre. 2 ♦ Biol. Action de doubler (intr.). Duplication …   Encyclopédie Universelle

  • Duplication — Duplication, duplicate, and duplicator may refer to: Art and fiction Duplicate (1998 film), a Bollywood film directed by Mahesh Bhatt Duplicate (2009 film), a 2009 Malayalam film Gregory Harrison and Kim Greist The Duplicate, a children s book by …   Wikipedia

  • duplication — du pli*ca tion, n. [L. duplicatio: cf. F. duplication.] 1. The act of duplicating, or the state of being duplicated; a doubling; a folding over; a fold. [1913 Webster] 2. (Biol.) The act or process of dividing by natural growth or spontaneous… …   The Collaborative International Dictionary of English

  • duplication — du·pli·ca·tion /ˌdü pli kā shən, ˌdyü / n: the act, process, or result of duplicating Merriam Webster’s Dictionary of Law. Merriam Webster. 1996. duplication …   Law dictionary

  • duplication — DUPLICATION. s. fém. Terme de Géométrie. Il n est guère d usage que dans cette phrase, La duplication du cube, pour signifier Le problème par lequel on demande de trouver un cube double d un autre …   Dictionnaire de l'Académie Française 1798

  • duplication — duplication. См. дупликация. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Duplication de l'A.D.N. — ● Duplication de l A.D.N. division d une molécule d acide désoxyribonucléique en deux molécules filles identiques …   Encyclopédie Universelle

  • duplication — early 15c., doubling, from M.Fr. duplicacion (13c.) and directly from L. duplicationem (nom. duplicatio), noun of action from pp. stem of duplicare (see DUPLICATE (Cf. duplicate)). Meaning repetition is from 1580s …   Etymology dictionary

  • duplication — [do͞o΄pli kā′shən, dyo͞o΄pli kā′shən] n. [ME duplicacioun < L duplicatio] 1. a duplicating or being duplicated 2. a copy; replica duplicative adj …   English World dictionary

  • Duplication — Cette page d’homonymie répertorie les différents sujets et articles partageant un même nom. Sur les autres projets Wikimedia : « Duplication », sur le Wiktionnaire (dictionnaire universel) D une manière générale, Le mot duplication …   Wikipédia en Français

  • duplication — duplicate du‧pli‧cate 2 [ˈdjuːplkeɪt ǁ ˈdu ] verb [transitive] to repeat, perhaps unnecessarily, something that has already been done: • Duplicating research is costly and time consuming. • The report merely duplicates earlier findings.… …   Financial and business terms

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