fructose-bisphosphate aldolase

Fructose-1,6-bisphosphate triophosphate-lyase; an enzyme reversibly cleaving fructose 1,6-bisphosphate to dihydroxyacetone phosphate and glyceraldehyde 3-phosphate; also acts on certain ketose 1-phosphates; deficient in individuals with hereditary fructose intolerance (aldolase B); a deficiency of aldolase A leads to erythrocyte aldolase deficiency with nonspherocytic hemolytic anemia. Cf.:hereditary fructose intolerance. SYN: 1-phosphofructaldolase, fructose-diphosphate aldolase.

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fruc·tose-bis·phos·phate al·do·lase (frookґtōs bis-fosґfāt alґdo-lās) [EC 4.1.2.13] an enzyme of the lyase class that catalyzes the cleavage of fructose 1,6-bisphosphate to form dihydroxyacetone phosphate and glyceraldehyde 3-phosphate, a reaction of the Embden-Meyerhof pathway (see illustration under pathway). The enzyme also catalyzes the conversion of fructose 1-phosphate to dihydroxyacetone phosphate and glyceraldehyde. Three isozymes are recognized: A (occurring primarily in skeletal muscle), B (in liver, kidney, small intestine, and leukocytes), and C (in brain). Isozyme B, often referred to as fructose 1-phosphate aldolase, has greater affinity for fructose 1-phosphate. Deficiency of the latter activity, an autosomal recessive trait, results in hereditary fructose intolerance. Called also aldolase.